Wang Shige, Zhao Jiulong, Yang Hailun, Wu Chenyao, Hu Fei, Chang Haizhou, Li Guixiang, Ma Dan, Zou Duowu, Huang Mingxian
College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China.
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Acta Biomater. 2017 Aug;58:442-454. doi: 10.1016/j.actbio.2017.06.014. Epub 2017 Jun 10.
Two-dimensional transition metal dichalcogenides (TMDs) have been receiving great attention as NIR photothermal transducing agent in tumor photothermal therapy. Keeping in mind the low efficiency of the conventional top-down exfoliated 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot hydrothermal and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS nanosheets. The material design was based on the chelating-coordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten. The WS nanosheets with synchronous surface PVP grafting showed an excellent photothermal conversion performance, while the surface anchored PVP guaranteed its colloidal stability. Moreover, the strong X-ray attenuation ability and near-infrared (NIR) absorbance of WS-PVP enabled the sensitive in vitro and in vivo computed tomography and photoacoustic imaging. The WS-PVP nanosheets were biocompatible and exhibited promising in vitro and in vivo anti-cancer efficacy. Findings in this report may greatly promote the design of colloidal stable and biocompatible 2D TMDs and their future clinical translations.
A bottom-up strategy for the one-pot and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS nanosheets was proposed for the first time. By hydrothermally treating the mixture solution of tetrathiotungstate and PVP, Owing to the chelating-coordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten, PVP was synchronously graphed on WS-PVP nanosheets surface. The formed WS-PVP nanosheets were colloidal stable, biocompatible, and exhibited promising computed tomography, photoacoustic imaging and tumor photothermal therapy efficacy both in vitro and in vivo.
二维过渡金属二硫属化物（TMDs）作为肿瘤光热治疗中的近红外光热转换剂受到了广泛关注。考虑到传统自上而下剥离的二维TMDs效率低下及其表面修饰的复杂性，我们在此提出了一种自下而上的策略，用于一锅水热法可控合成表面聚乙烯吡咯烷酮（PVP）修饰的WS纳米片。材料设计基于PVP羰基氧的孤对电子与钨的未占据轨道（5d轨道）之间的螯合配位作用。具有同步表面PVP接枝的WS纳米片表现出优异的光热转换性能，而表面锚定的PVP保证了其胶体稳定性。此外，WS-PVP的强X射线衰减能力和近红外（NIR）吸收能力使其能够进行灵敏的体外和体内计算机断层扫描和光声成像。WS-PVP纳米片具有生物相容性，并在体外和体内展现出有前景的抗癌效果。本报告中的发现可能会极大地促进胶体稳定且生物相容的二维TMDs的设计及其未来的临床转化。
首次提出了一种自下而上的策略，用于一锅法可控合成表面聚乙烯吡咯烷酮（PVP）修饰的WS纳米片。通过对钨酸四硫盐水溶液和PVP的混合溶液进行水热处理，由于PVP羰基氧的孤对电子与钨的未占据轨道（5d轨道）之间的螯合配位作用，PVP同步接枝在WS纳米片表面。所形成的WS-PVP纳米片具有胶体稳定性、生物相容性，并且在体外和体内均展现出有前景的计算机断层扫描、光声成像及肿瘤光热治疗效果。
