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角膜生物力学:综述

Corneal biomechanics: a review.

作者信息

Piñero David P, Alcón Natividad

机构信息

Department of Ophthalmology (Oftalmar), Medimar International Hospital, Alicante, Spain; Foundation for the Visual Quality, Fundación para la Calidad Visual, Alicante, Spain; Departament of Optics, Pharmacology and Anatomy, University of Alicante, Spain.

出版信息

Clin Exp Optom. 2015 Mar;98(2):107-16. doi: 10.1111/cxo.12230. Epub 2014 Dec 2.

Abstract

Biomechanics is often defined as 'mechanics applied to biology'. Due to the variety and complexity of the behaviour of biological structures and materials, biomechanics is better defined as the development, extension and application of mechanics for a better understanding of physiology and physiopathology and consequently for a better diagnosis and treatment of disease and injury. Different methods for the characterisation of corneal biomechanics are reviewed in detail, including those that are currently commercially available (Ocular Response Analyzer and CorVis ST). The clinical applicability of the parameters provided by these devices are discussed, especially in the fields of glaucoma, detection of ectatic disorders and orthokeratology. Likewise, other methods are also reviewed, such as Brillouin microscopy or dynamic optical coherence tomography and others with potential application to clinical practice but not validated for in vivo measurements, such as ultrasonic elastography. Advantages and disadvantages of all these techniques are described. Finally, the concept of biomechanical modelling is revised as well as the requirements for developing biomechanical models, with special emphasis on finite element modelling.

摘要

生物力学通常被定义为“应用于生物学的力学”。由于生物结构和材料行为的多样性和复杂性,生物力学更确切地定义为力学的发展、延伸和应用,以便更好地理解生理学和病理生理学,从而更好地诊断和治疗疾病与损伤。详细综述了表征角膜生物力学的不同方法,包括目前市面上可用的方法(眼反应分析仪和CorVis ST)。讨论了这些设备所提供参数的临床适用性,尤其是在青光眼、扩张性疾病检测和角膜塑形术等领域。同样,也综述了其他方法,如布里渊显微镜或动态光学相干断层扫描,以及其他有潜在临床应用价值但尚未在体内测量中得到验证的方法,如超声弹性成像。描述了所有这些技术的优缺点。最后,对生物力学建模的概念以及开发生物力学模型的要求进行了修订,特别强调了有限元建模。

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