Yang Zhengfei, Wu Bo, Li Zhouyue, Yu Mengting, Jiang Jinyun, Chen Shuyuan, Xu Shengsong, Zeng Junwen, Wang Mengyi, Yang Xiao
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
South China Hospital, Shenzhen University, Shenzhen, China.
J Ophthalmol. 2023 Oct 14;2023:6680748. doi: 10.1155/2023/6680748. eCollection 2023.
To determine three-year change of the corneal biomechanical parameter stress-strain index (SSI) in schoolchildren aged 7- 9 years and their correlation with refractive error and axial length (AL).
This is a prospective cohort study. Data of the AL, refractive error, and corneal biomechanical parameter SSI were collected at baseline and a 3-year follow-up for 217 schoolchildren. SSI, AL, and refractive error were measured via corneal visualization Scheimpflug technology (Corvis ST), IOLMaster biometry, and cycloplegic refraction. Three years of changes in SSI and its association with refractive error and AL were analyzed. Participants were divided into persistent nonmyopia (PNM), newly developed myopia (NDM), and persistent myopia (PM). The three-year difference in SSI among the three groups was analyzed.
After three years of follow-up, the corneal biomechanical parameter SSI decreased in all participants ( < 0.01). There was a negative correlation between the change in SSI and the change in AL ( = -0.205, =0.002) and a positive correlation between the change in refractive error ( = 0.183, =0.007). After three years of follow-up, there was a decrease in the SSI for the NDM, PM, and PNM participants, with a median change of -0.05 for PNM and -0.13 and -0.09 for the NDM and PM, respectively. There was a significant decrease in corneal biomechanical properties for NDM patients compared with PNM patients ( < 0.01).
In 7- to 9-year-old schoolchildren, SSI decreased after three years of the longitudinal study, and the change in SSI was correlated with the change in AL and refractive error. There was a rapid decrease in corneal biomechanical properties among newly developed myopic patients.
确定7至9岁学龄儿童角膜生物力学参数应力应变指数（SSI）的三年变化情况及其与屈光不正和眼轴长度（AL）的相关性。
这是一项前瞻性队列研究。收集了217名学龄儿童在基线时以及3年随访时的AL、屈光不正和角膜生物力学参数SSI的数据。通过角膜可视化Scheimpflug技术（Corvis ST）、IOLMaster生物测量法和散瞳验光测量SSI、AL和屈光不正。分析了SSI的三年变化及其与屈光不正和AL的关联。参与者被分为持续性非近视（PNM）、新发性近视（NDM）和持续性近视（PM）。分析了三组之间SSI的三年差异。
经过三年随访，所有参与者的角膜生物力学参数SSI均下降（<0.01）。SSI的变化与AL的变化呈负相关（=-0.205，=0.002），与屈光不正的变化呈正相关（=0.183，=0.007）。经过三年随访，NDM、PM和PNM参与者的SSI均下降，PNM的中位数变化为-0.05，NDM和PM分别为-0.13和-0.09。与PNM患者相比，NDM患者的角膜生物力学特性显著下降（<0.01）。
在7至9岁的学龄儿童中，经过三年的纵向研究，SSI下降，且SSI的变化与AL和屈光不正的变化相关。新发性近视患者的角膜生物力学特性迅速下降。
