Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
The First People's Hospital of Xuzhou, Xuzhou, China.
Sci Rep. 2024 Sep 17;14(1):21713. doi: 10.1038/s41598-024-72054-2.
To report the correlation between corneal biomechanical parameters and age in healthy Chinese individuals. This cross-sectional study was conducted on 864 eyes of 543 healthy participants. A comprehensive ophthalmic examination and corneal biomechanics examination using Corneal Visualization Scheimpflug Technology (Corvis ST) were conducted. Based on age, all participants were further divided into five age groups (n) as follows: group A, 11-20 years (105); group B, 21-30 years (112); group C, 31-40 years (113); group D, 41-50 years (100); and group E, > 50 years (113). Using Corvis ST, we examined 35 corneal biomechanical parameters and compared them across the different age groups. Spearman's correlation coefficients and stepwise multivariate linear regression models were used to investigate whether the corneal biomechanical parameters were related to demographic and ocular characteristics. A correlation analysis between the left and right eyes revealed that 13 parameters were significantly associated with eye differences. Among the 35 corneal biomechanical parameters, 28 exhibited significant differences across the age groups, with stiffness parameter at applanation 1(SPA1) showing an upward trend after the age of 30 and stress-strain index (SSI) demonstrates a statistically significant upward trend when comparing the five age groups in the study. Additionally, Spearman's correlation analysis and stepwise multivariate linear regression analysis revealed that 11 corneal biomechanical parameters were positively correlated with age and 10 were negatively correlated with age. Corvis biomechanical index (CBI) was significantly negatively correlated with intraocular pressure (IOP) and central corneal thickness (CCT), SSI was significantly positively correlated with age and IOP, and SPA1 were positively correlated with IOP and CCT. In conclusion, most corneal biomechanical parameters showed a significant correlation with age, with corneal stiffness progressively increasing alongside advancing age, IOP, or CCT.
报告健康中国人眼角膜生物力学参数与年龄的相关性。本研究为横断面研究，共纳入 543 名健康志愿者的 864 只眼。所有参与者均接受全面眼科检查和基于角膜可视化Scheimpflug 技术（Corvis ST）的角膜生物力学检查。根据年龄，所有参与者被进一步分为 5 个年龄组（n）：A 组，11-20 岁（105 只眼）；B 组，21-30 岁（112 只眼）；C 组，31-40 岁（113 只眼）；D 组，41-50 岁（100 只眼）；E 组，>50 岁（113 只眼）。使用 Corvis ST，我们检测了 35 个眼角膜生物力学参数，并比较了不同年龄组之间的差异。采用 Spearman 相关系数和逐步多元线性回归模型，探讨角膜生物力学参数与人口统计学和眼部特征的相关性。左右眼相关性分析显示，有 13 个参数与眼间差异显著相关。在 35 个角膜生物力学参数中，有 28 个参数在不同年龄组之间存在显著差异，其中，在 30 岁以后，压平 1 区刚性参数（SPA1）呈上升趋势，而在研究中比较 5 个年龄组时，应变量比（SSI）呈显著上升趋势。此外，Spearman 相关分析和逐步多元线性回归分析显示，有 11 个角膜生物力学参数与年龄呈正相关，10 个参数与年龄呈负相关。Corvis 生物力学指数（CBI）与眼压（IOP）和中央角膜厚度（CCT）显著负相关，SSI 与年龄和 IOP 显著正相关，而 SPA1 与 IOP 和 CCT 呈正相关。总之，大多数眼角膜生物力学参数与年龄显著相关，随着年龄的增长，角膜硬度逐渐增加，IOP 或 CCT 也随之增加。
