肠内分泌 MC4R 与能量平衡：长短相连。
Enteroendocrine MC4R and energy balance: linking the long and the short of it.
机构信息
Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; School of Medicine, University College Cork, Cork, Ireland.
Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK.
出版信息
Cell Metab. 2014 Dec 2;20(6):929-31. doi: 10.1016/j.cmet.2014.11.014.
Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance. In this issue, Panaro et al. (2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.
中央 MC4R 通路在外周信号整合中对能量平衡的控制中起着重要作用。在本期杂志中，Panaro 等人（2014）发现，肠道内分泌 L 细胞上表达的 MC4R 调节 PYY 和 GLP-1 的分泌，这两种肠道激素与能量和葡萄糖稳态的调节有关。
Zotero 插件