Graffigna Mabel Nora, Berg Gabriela, Migliano Marta, Salgado Pablo, Soutelo Jimena, Musso Carla
Department of Diabetes and Lipid Metabolism, Society of Endocrinology and Metabolism, Buenos Aires, Argentina; Endocrinology Division, Carlos Durand Hospital, Buenos Aires, Argentina.
Clinical Biochemistry Department, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):24-7. doi: 10.1016/j.dsx.2014.05.005. Epub 2014 Jun 16.
Cardiovascular disease (CVD) is currently the primary cause of morbidity and mortality.
(1) Assess the 10 years risk for CVD in Argentinean blood donors, according to Framingham score (updated by ATP III), (2) evaluate the prevalence of the MS, (3) evaluate non HDL-cholesterol level in this population as other risk for CVD.
A prospective, epidemiological, transversal study was performed to evaluate 585 volunteer blood donors for two years. Non HDL-C was calculated as total cholesterol minus HDL-C and we evaluated the 10 years risk for CVD according to Framingham score (updated by ATP III).
Metabolic syndrome prevalence was estimated according to ATP III and IDF criteria. Non HDL-C was (media±SD) 178.3±48.0 mg/dl in participants with MS and 143.7±39.3 mg/dl without MS (ATPIII) and 160.1±43.6 mg/dl in participants with MS and 139.8±43.1 mg/dl without MS (IDF). Participants with MS presented an OR of 3.1; IC 95% (2-5) of CVD according to de Framingham score.
Individuals with MS and elevated non HDL-C are at a higher estimated risk for cardiovascular events in the next 10 years according to the Framingham risk score.
心血管疾病（CVD）目前是发病和死亡的主要原因。
（1）根据弗明汉姆评分（由ATP III更新）评估阿根廷献血者患心血管疾病的10年风险，（2）评估代谢综合征（MS）的患病率，（3）评估该人群中非高密度脂蛋白胆固醇水平作为心血管疾病的其他风险因素。
进行了一项前瞻性、流行病学横断面研究以评估585名志愿献血者，为期两年。非高密度脂蛋白胆固醇（Non HDL-C）通过总胆固醇减去高密度脂蛋白胆固醇来计算，我们根据弗明汉姆评分（由ATP III更新）评估心血管疾病的10年风险。
根据ATP III和国际糖尿病联盟（IDF）标准估计代谢综合征患病率。患有代谢综合征的参与者中非高密度脂蛋白胆固醇水平为（中位数±标准差）178.3±48.0mg/dl，未患代谢综合征者为143.7±39.3mg/dl（ATPIII）；患有代谢综合征的参与者中非高密度脂蛋白胆固醇水平为160.1±43.6mg/dl，未患代谢综合征者为139.8±43.1mg/dl（IDF）。根据弗明汉姆评分，患有代谢综合征者患心血管疾病的比值比为3.1；95%置信区间（2 - 5）。
根据弗明汉姆风险评分，患有代谢综合征且非高密度脂蛋白胆固醇升高的个体在未来10年发生心血管事件的估计风险更高。
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