Hossein Gozashti Mohammad, Maryam Shafiei, Saeed Esmaeilian, Hamid Najafipour, Mahdieh Mashrouteh
Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Diabetes Metab Syndr. 2015 Apr-Jun;9(2):104-7. doi: 10.1016/j.dsx.2014.04.014. Epub 2014 May 22.
Latent autoimmune diabetes in adults [LADA] is a type of autoimmune diabetes in adults that is usually identified by positive GAD-antibody [glutamic acid decarboxylase]. Epidemiological studies show that this disease has no identified prevalence and incidence in Asia due to the various criteria in diagnosing the disease.
500 patients with type 2 diabetes based on American Diabetes Association [ADA] criteria and age of diabetes onset above 35 years old who needed no insulin until at least 6 months after the diagnosis of diabetes were selected from KERCADR Study and their anti-GAD serum level was determined.
From 500 patients, 429 ones [85%] were negative and 71 ones [14.2%] were positive for GAD antibody. The prevalence of latent autoimmune diabetes was higher in the age group of 50-59 years compared to the other age groups. There was no significant correlation between LADA and hypertension, family history of diabetes, cigarette smoking and tobacco use.
The prevalence rate of latent autoimmune diabetes in adults in patients with type 2 diabetes was 14.2% and we could not find any relationship.
成人隐匿性自身免疫性糖尿病[LADA]是一种成人自身免疫性糖尿病，通常通过谷氨酸脱羧酶抗体[GAD]呈阳性来识别。流行病学研究表明，由于诊断该疾病的标准各不相同，在亚洲尚未确定其患病率和发病率。
从KERCADR研究中选取500例符合美国糖尿病协会[ADA]标准的2型糖尿病患者，糖尿病发病年龄在35岁以上，且在糖尿病诊断后至少6个月内无需胰岛素治疗，测定其血清抗GAD水平。
500例患者中，429例（85%）GAD抗体呈阴性，71例（14.2%）呈阳性。与其他年龄组相比，50-59岁年龄组的成人隐匿性自身免疫性糖尿病患病率更高。LADA与高血压、糖尿病家族史、吸烟和使用烟草之间无显著相关性。
2型糖尿病患者中成人隐匿性自身免疫性糖尿病的患病率为14.2%，且我们未发现任何相关性。
