Nerschbach V, Eberle N, Joetzke A E, Hoeinghaus R, Hungerbuehler S, Mischke R, Nolte I, Betz D
Small Animal Hospital of the University of Veterinary Medicine, Hannover, Germany.
Vet Comp Oncol. 2016 Aug;14 Suppl 1:82-94. doi: 10.1111/vco.12127. Epub 2014 Dec 3.
Stage migration is described in humans and dogs as a sequel of using more sensitive diagnostic methods. One hundred eighty-six dogs with multicentric lymphoma were enrolled with results of conventional staging as well as ultrasonographic and cytological examination of liver and spleen being available. The addition of splenic respective hepatic ultrasound and cytology findings resulted in slightly lower number of dogs classified as having liver and spleen involvement. In dogs with multicentric lymphoma, addition of cytology led to a significant shift of individuals from stage IV to stage III. Findings of hepatic and splenic ultrasound and cytology exerted no significant influence on complete remission and survival durations in dogs with combination chemotherapy. Staging methodology in canine lymphoma should be redefined, considering that the prognostic significance of splenic and hepatic ultrasound and cytology warrants further investigation.
在人类和犬类中,随着使用更敏感的诊断方法,出现了分期迁移的现象。186只患有多中心淋巴瘤的犬只参与了研究,这些犬只既有传统分期的结果,也有肝脏和脾脏的超声检查及细胞学检查结果。脾脏及肝脏超声检查和细胞学检查结果的补充,使被归类为肝脏和脾脏受累的犬只数量略有减少。在患有多中心淋巴瘤的犬只中,细胞学检查结果导致个体从IV期显著转移至III期。肝脏和脾脏超声检查及细胞学检查结果对接受联合化疗的犬只的完全缓解率和生存期没有显著影响。鉴于脾脏和肝脏超声检查及细胞学检查的预后意义值得进一步研究,犬淋巴瘤的分期方法应重新定义。