α-黑素细胞刺激素样免疫反应性在两栖类骨骼肌神经支配中的存在。

Presence of alpha-melanocyte-stimulating hormone-like immunoreactivity in the innervation of amphibian skeletal muscle.

作者信息

Oren N, Micevych P E, Letinsky M S

机构信息

Department of Physiology, University of California, Los Angeles 90024-1751.

出版信息

J Neurosci Res. 1989 Jun;23(2):225-33. doi: 10.1002/jnr.490230213.

DOI:10.1002/jnr.490230213

PMID:2547085

Abstract

Amphibian motor nerve terminals are sensitive to a wide variety of peptides, including alpha-melanocyte-stimulating hormone (alpha-MSH). We determined the presence and distribution of alpha-MSH-like immunoreactivity (alpha-MSHLI) in the innervation of the cutaneous pectoris muscle from bullfrog (Rana catesbeiana) tadpoles and postmetamorphic froglets, and adult frogs (R. catesbeiana and R. pipiens). alpha-MSHLI was found in unmyelinated, noncholinergic axons, in motor axons, and in motor nerve terminals. In motor axons, alpha-MSHLI was predominantly associated with neurofilaments. The distribution of this form of alpha-MSHLI changed during development and seasonally in adult frogs. The possible functional roles of this alpha-MSHLI are discussed.

摘要

两栖动物的运动神经末梢对多种肽敏感，包括α-黑素细胞刺激素（α-MSH）。我们确定了牛蛙（牛蛙）蝌蚪、变态后幼蛙和成年蛙（牛蛙和豹蛙）胸皮肌神经支配中α-MSH样免疫反应性（α-MSHLI）的存在和分布。α-MSHLI存在于无髓非胆碱能轴突、运动轴突和运动神经末梢中。在运动轴突中，α-MSHLI主要与神经丝相关。这种形式的α-MSHLI的分布在发育过程中以及成年蛙的季节性变化中发生改变。文中讨论了这种α-MSHLI可能的功能作用。