Ozeretskovskaia N N, Kulinich G V, Firsova R A, Panteleeva E A
Med Parazitol (Mosk). 1989 Mar-Apr(2):51-4.
Efficacity of tiniba (tinidasole, Kadila, India) and of fasigyn (Polfa, Poland) dosed 300 mg daily for 7 days was 87.5 and 85.2% (P greater than 0.05) immediately after treatment and 45.5 and 50.0% (P greater than 0.05) 4-8 months later, respectively. The lack of parasitocidal effect was established in 4 out of 27 tiniba-treated patients and in 3 out of 24 fasigyn treated ones. Direct correlation between the efficacy of persisting giardia infection chemotherapy and the cAMP phosphodiesterase activity in blood lymphocytes was found previously. Authors established an indirect correlation between the former and hydrochloric acid secretion by the bowel.
印度卡迪拉公司生产的替硝唑（tiniba）和波兰波尔法公司生产的法西吉农（fasigyn），每日剂量300毫克，连用7天，治疗结束后立即观察到的疗效分别为87.5%和85.2%（P>0.05），4至8个月后分别为45.5%和50.0%（P>0.05）。接受替硝唑治疗的27例患者中有4例以及接受法西吉农治疗的24例患者中有3例未出现杀寄生虫效果。先前已发现持续的贾第鞭毛虫感染化疗疗效与血液淋巴细胞中的环磷酸腺苷磷酸二酯酶活性之间存在直接相关性。作者们发现前者与肠道盐酸分泌之间存在间接相关性。
