May Ole, Lynggaard Vibeke, Mortensen Jesper C A, Malczynski Jerzy
Department of Medicine, Regional Hospital West Jutland , Denmark.
Scand Cardiovasc J. 2015 Feb;49(1):1-6. doi: 10.3109/14017431.2014.994028. Epub 2015 Jan 22.
Enhanced external counterpulsation (EECP) is a new therapy offered to patients with refractory angina pectoris (AP).
To assess the effect of EECP on AP, quality of life (QoL) and exercise capacity in a design starting with a control period to avoid the influence of regression-towards-the-mean.
Patients were examined two months before EECP, just before, just after, and three and 12 months after EECP. EECP was given for 1 h 5 days a week in 7 weeks. Three sets of pneumatic cuffs were mounted on the lower extremities and inflated sequentially in diastole to 260 mm Hg.
50 patients were included (male 72%, mean age: 62.5 years). Mean daily AP attacks were reduced during EECP from 2.7 to 0.9 (p < 0.005) and the Canadian Cardiovascular Society classification was reduced by at least 1 class in 82% just after EECP, 79% 3 months and 76% 12 months after EECP (p < 0.0002). Generic (SF36) and disease-specific QoL (Seattle AP questionnaire) improved just after, 3 and 12 months after compared with that before EECP. There was a significant improvement in exercise capacity and exercise-induced chest pain just after, three and 12 months after EECP (p < 0.02). No change was detected during the control period.
EECP improves generic and disease-specific QoL, angina intensity and exercise capacity in at least 12 months.
增强型体外反搏（EECP）是一种为顽固性心绞痛（AP）患者提供的新疗法。
在一个从对照期开始的设计中评估EECP对AP、生活质量（QoL）和运动能力的影响，以避免均值回归的影响。
在EECP治疗前两个月、即将进行EECP时、刚完成EECP后以及EECP后3个月和12个月对患者进行检查。EECP每周5天，每天进行1小时，共持续7周。在下肢安装三组气动袖带，并在舒张期依次充气至260毫米汞柱。
纳入50例患者（男性占72%，平均年龄：62.5岁）。在EECP治疗期间，每日平均AP发作次数从2.7次降至0.9次（p<0.005），加拿大心血管学会分级在EECP刚结束后至少降低1级的患者占82%，EECP后3个月为79%，12个月为76%（p<0.0002）。与EECP治疗前相比，在EECP刚结束后、3个月和12个月时，通用（SF36）和疾病特异性QoL（西雅图AP问卷）均有所改善。在EECP刚结束后、3个月和12个月时，运动能力和运动诱发的胸痛有显著改善（p<0.02）。在对照期未检测到变化。
EECP在至少12个月内可改善通用和疾病特异性QoL、心绞痛强度及运动能力。
