Yin Shufei, Zhu Xinyi, Li Rui, Niu Yanan, Wang Baoxi, Zheng Zhiwei, Huang Xin, Huo Lijuan, Li Juan
1] Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [2] University of Chinese Academy of Sciences, Beijing, China.
Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Sci Rep. 2014 Dec 4;4:7309. doi: 10.1038/srep07309.
This study examined the effects of a multimodal intervention on spontaneous brain activity in healthy older adults. Seventeen older adults received a six-week intervention that consisted of cognitive training, Tai Chi exercise, and group counseling, while 17 older adults in a control group attended health knowledge lectures. The intervention group demonstrated enhanced memory and social support compared to the control group. The amplitude of low frequency fluctuations (ALFF) in the middle frontal gyrus, superior frontal gyrus, and anterior cerebellum lobe was enhanced for the intervention group, while the control group showed reduced ALFF in these three regions. Moreover, changes in trail-making performance and well-being could be predicted by the intervention-induced changes in ALFF. Additionally, individual differences in the baseline ALFF were correlated with intervention-related changes in behavioral performance. These findings suggest that a multimodal intervention is effective in improving cognitive functions and well-being and can induce functional changes in the aging brain. The study extended previous training studies by suggesting resting-state ALFF as a marker of intervention-induced plasticity in older adults.
本研究考察了多模式干预对健康老年人自发脑活动的影响。17名老年人接受了为期六周的干预，包括认知训练、太极拳锻炼和团体咨询，而对照组的17名老年人参加了健康知识讲座。与对照组相比，干预组的记忆力和社会支持得到增强。干预组中额回、额上回和小脑前叶的低频波动幅度（ALFF）增强，而对照组在这三个区域的ALFF降低。此外，干预引起的ALFF变化可以预测连线测验表现和幸福感的变化。此外，基线ALFF的个体差异与行为表现的干预相关变化相关。这些发现表明，多模式干预在改善认知功能和幸福感方面是有效的，并且可以诱导衰老大脑的功能变化。该研究通过将静息态ALFF作为老年人干预诱导可塑性的标志物，扩展了先前的训练研究。
