背外侧延髓梗死所致神经营养性角膜病变（瓦伦贝格综合征）：病例报告及文献综述
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review.
作者信息
Wu Songdi, Li Ningning, Xia Feng, Sidlauskas Kastytis, Lin Xuemei, Qian Yihua, Gao Wei, Zhang Qinlu
机构信息
Department of Neurology, First Hospital of Xi'an, Xi'an 710002, Shaanxi, China.
出版信息
BMC Neurol. 2014 Dec 4;14:231. doi: 10.1186/s12883-014-0231-y.
BACKGROUND
Dorsolateral medullary infarction (Wallenberg syndrome) is rare in clinical practice; however, the subsequent corneal lesions are more uncommon. To our knowledge, only one such case was previously reported. We report a similar case with successful treatment and recovery, and analyse both cases to address the clinical features and outcomes of such syndrome.
CASE PRESENTATION
A 43-year-old male presented with neurotrophic keratopathy one month after sustaining dorsolateral medullary infarction. The patient underwent amniotic membrane transplantation twice. Two-year follow-up observation revealed changes in nerve fibers and epithelial cells of corneal by laser confocal microscopy.
CONCLUSION
By studying both cases, we confirm that neurotrophic keratopathy could be as a delayed-onset complication of Wallenberg syndrome. The recognition that neurotrophic keratopathy can follow dorsolateral medullary infarction could prevent the clinical misdiagnosis.
背景
延髓背外侧梗死（Wallenberg综合征）在临床实践中较为罕见；然而，随后出现的角膜病变则更为少见。据我们所知，此前仅报道过1例此类病例。我们报告1例经成功治疗并康复的类似病例，并对这2例病例进行分析，以探讨该综合征的临床特征和转归。
病例介绍
1例43岁男性在发生延髓背外侧梗死后1个月出现神经营养性角膜病变。该患者接受了2次羊膜移植。2年的随访观察通过激光共聚焦显微镜检查发现了角膜神经纤维和上皮细胞的变化。
结论
通过对这2例病例的研究，我们证实神经营养性角膜病变可能是Wallenberg综合征的迟发性并发症。认识到神经营养性角膜病变可继发于延髓背外侧梗死有助于防止临床误诊。
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