延髓背外侧梗死注册研究：一项前瞻性、多中心注册研究方案。

Dorsolateral medullary infarction registry: a study protocol for a prospective, multicentric registry.

机构信息

Department of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.

Department of Neurology, the First Affiliated Hospital of Northwestern University, 710002, Xi'an, Shaanxi Province, China.

出版信息

BMC Neurol. 2021 Jan 12;21(1):18. doi: 10.1186/s12883-020-02030-6.

DOI:10.1186/s12883-020-02030-6

PMID:33435910

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7801561/

Abstract

BACKGROUND

Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction.

METHODS

This study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period.

DISCUSSION

This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea.

TRIAL REGISTRATION

The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.

摘要

背景

延髓背外侧梗死是一种典型的脑梗死，其特征是 Wallenberg 综合征。神经营养性角膜病变是延髓背外侧梗死的一种罕见后果。目前，该方案旨在研究延髓背外侧梗死后角膜神经支配和眼表环境的动态变化。

方法

本研究将纳入来自 10 个合作卒中中心神经内科的 10 个连续数据，这些数据来自于急性延髓背外侧梗死发病后 7 天内的所有患者的病历。符合条件的患者主要基于详细的体格检查、多模态成像和角膜相关检查进行特征描述，并将进行为期 2 年的随访。延髓背外侧梗死后的神经营养性角膜病变是主要终点。在随访期间，将观察延髓背外侧梗死后角膜神经支配和眼表环境的动态组织学变化。