吲哚美辛和依那普利对皮肤对缓激肽反应的影响。
The effect of indomethacin and enalapril on the cutaneous response to bradykinin.
作者信息
McAlpine L G, Thomson N C
机构信息
Department of Respiratory Medicine, Western Infirmary, Glasgow.
出版信息
Br J Clin Pharmacol. 1989 Jun;27(6):870-2. doi: 10.1111/j.1365-2125.1989.tb03452.x.
Abstract
The angiotensin converting enzyme inhibitors potentiate the wheal response to intradermal bradykinin. Both converting enzyme inhibitors and bradykinin stimulate prostaglandin synthesis and prostaglandins enhance the cutaneous response to bradykinin. We examined the possibility that the increased wheal response to intradermal bradykinin in the presence of enalapril was due to the effect of prostaglandins. Indomethacin did not inhibit the potentiation by enalapril of the wheal response to bradykinin.
摘要
血管紧张素转换酶抑制剂可增强对皮内注射缓激肽的风团反应。转换酶抑制剂和缓激肽均可刺激前列腺素合成，且前列腺素可增强皮肤对缓激肽的反应。我们研究了在依那普利存在的情况下，皮内注射缓激肽后风团反应增强是否是由于前列腺素的作用。吲哚美辛并未抑制依那普利对缓激肽风团反应的增强作用。
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