Lawson Jack, Elliott Jonathan, Wheeler-Jones Caroline, Syme Harriet, Jepson Rosanne
Comparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
Comparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
Vet J. 2015 Jan;203(1):18-26. doi: 10.1016/j.tvjl.2014.10.009. Epub 2014 Oct 24.
Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD.
慢性肾脏病（CKD）是老年猫常见的病症。在大多数情况下，潜在病因不明，但最常报告的病理诊断是肾小管间质纤维化。肾纤维化的特征是间质内细胞外基质大量积聚，被认为是所有肾脏疾病的最终共同途径，并且是与人类和猫的肾功能最密切相关的病理病变。作为一个汇聚途径，肾纤维化为CKD的治疗提供了理想靶点，了解潜在的纤维化过程对于新型疗法的未来发展至关重要。文献中报道了许多肾纤维化的介质和机制，其中只有少数在猫身上进行了研究。本文综述了肾纤维化的过程，并讨论了最常被提及的进行性肾损伤的介质和机制，特别关注其对猫CKD的潜在意义。
