Abraham W M
Harry Pearlman Biomedical Research Institute, Mount Sinai Medical Center, Miami Beach, Florida.
Drugs. 1989;37 Suppl 1:78-86; discussion 127-36. doi: 10.2165/00003495-198900371-00015.
We studied the effects of nedocromil sodium and sodium cromoglycate on early and late bronchial responses, the airway inflammation associated with the late response to inhaled Ascaris suum antigen in allergic sheep in vivo, and the antigen-induced contractile responses of sheep tracheal smooth muscle in vitro. In addition, we examined the effect of nedocromil sodium on the development of antigen-induced airway hyper-responsiveness in this model. Pretreatment with either nedocromil sodium or sodium cromoglycate was effective in blocking antigen-induced early and late responses in allergic sheep. Both drugs also prevented the influx of eosinophils into the airways as assessed by bronchoalveolar lavage, observed during the late response in this model. No difference in drug potency was observed in vivo, but in vitro nedocromil sodium was 10-fold more potent than sodium cromoglycate against antigen-induced contractions of sheep tracheal smooth muscle. Nedocromil sodium was effective in blocking antigen-induced late responses and the subsequent development of airway hyper-responsiveness irrespective of whether the drug was given before antigen challenge or after the immediate response to antigen but before the late response. These findings indicate that nedocromil sodium is effective in the sheep model of asthma and therefore may be beneficial in the treatment of reversible obstructive airway disease in man.
我们研究了奈多罗米钠和色甘酸钠对早期和晚期支气管反应、与变应性绵羊体内吸入猪蛔虫抗原的晚期反应相关的气道炎症以及体外绵羊气管平滑肌抗原诱导的收缩反应的影响。此外，我们在该模型中研究了奈多罗米钠对抗原诱导的气道高反应性发展的影响。用奈多罗米钠或色甘酸钠预处理可有效阻断变应性绵羊体内抗原诱导的早期和晚期反应。通过支气管肺泡灌洗评估，两种药物还可防止该模型晚期反应期间观察到的嗜酸性粒细胞流入气道。在体内未观察到药物效力的差异，但在体外，奈多罗米钠对抗原诱导的绵羊气管平滑肌收缩的效力比色甘酸钠强10倍。无论在抗原激发前给药还是在对抗原的即刻反应后但在晚期反应前给药，奈多罗米钠均可有效阻断抗原诱导的晚期反应以及随后气道高反应性的发展。这些发现表明，奈多罗米钠在绵羊哮喘模型中有效，因此可能对治疗人类可逆性阻塞性气道疾病有益。
