Gandini Roberto, Morosetti Daniele, Chiocchi Marcello, Chiaravalloti Antonio, Citraro Daniele, Loreni Giorgio, DA Ros Valerio, Salvatori Eva, Simonetti Giovanni
Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiation Therapy, University Hospital "Tor Vergata", Rome, Italy -
J Cardiovasc Surg (Torino). 2016 Oct;57(5):625-33. Epub 2014 Dec 5.
The aim of this study was to assess the technical success and clinical long-term results of renal artery aneurysm (RAA) treatment using covered stents.
We performed a retrospective study on endovascular treatment of nine patients with 10 RAAs, arising from the main renal artery or from the proximal portion of large segmental arteries. All procedures were performed in our department between 2004 and 2011. The aneurysms were excluded using covered stents. Our follow-up included laboratories indexes, Computed Tomography-angiography (CTA) at 1-6-12-24 months and 48-month Duplex-ultrasound examination.
Study population included 4 males and 5 females (mean age: 63.5±7.3 y.o.). Six were affected by fibromuscular dysplasia and associated renal artery stenosis. The population showed a significant decrease of arterial blood pressure (from baseline values of 163.9±19.4/98.9±9.2 mmHg to 128.9±6.5/79.4±4.6 mmHg at 24 months follow-up) and of drug posology (baseline 3.7±0.7 drugs to 1.6±0.7 drugs at 24 months). Also they showed a significant decrease of serum creatinine levels (baseline 1.9±1.4 mg/dL vs.1.1±0.4 mg/dL at 12 months) and increase of glomerular filtration rate (from baseline values 46.9±23 mL/min/1.73 m2 to 69.1±20 mL/min/1.73 m2 at 24 months follow-up). CTA demonstrated patency of the cover stents, absence of endoleaks and re-stenosis in all patients. Only in one patient the inferior segmental artery was sacrificed due to the presence of its early origin, resulting in a small area of renal parenchyma infarction with no significant clinical consequences.
The procedure revealed to be safe for renal function, feasible and effective for the exclusion of the aneurismal sac and restoring vessel patency.
本研究的目的是评估使用覆膜支架治疗肾动脉动脉瘤(RAA)的技术成功率和临床长期效果。
我们对9例患有10个肾动脉动脉瘤的患者进行了回顾性研究,这些动脉瘤起源于肾主动脉或大的节段动脉近端。所有手术均于2004年至2011年在我院进行。使用覆膜支架排除动脉瘤。我们的随访包括实验室指标、在1个月、6个月、12个月、24个月时的计算机断层血管造影(CTA)以及48个月时的双功超声检查。
研究人群包括4名男性和5名女性(平均年龄:63.5±7.3岁)。6例患有纤维肌性发育不良并伴有肾动脉狭窄。该人群的动脉血压显著下降(从基线值163.9±19.4/98.9±9.2 mmHg降至随访24个月时的128.9±6.5/79.4±4.6 mmHg)以及药物用量减少(基线时3.7±0.7种药物降至24个月时的1.6±0.7种药物)。他们还表现出血清肌酐水平显著下降(基线时1.9±1.4 mg/dL vs. 12个月时1.1±0.4 mg/dL)以及肾小球滤过率增加(从基线值46.9±23 mL/min/1.73 m²增至随访24个月时的69.1±20 mL/min/1.73 m²)。CTA显示所有患者的覆膜支架通畅,无内漏和再狭窄。仅1例患者因下段动脉起源较早而被牺牲,导致肾实质小面积梗死,无明显临床后果。
该手术对肾功能安全,对排除动脉瘤囊和恢复血管通畅可行且有效。