Yin Meng-Xin, Zhang Lei
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):39-45. doi: 10.1093/abbs/gmu111. Epub 2014 Dec 4.
Over the past decade, discoveries on Hippo signaling have revealed a complex signaling network integrating various signaling pathways to modulate tissue homeostasis, organ size control, tissue repair, and regeneration. Malfunction of the Hippo pathway is associated with tumor and cancer development. Moreover, Hippo signaling has been proposed to act in numerous stem cells in a variety of organisms. Recently, more attention has been paid to define the functions of the Hippo pathway in tissue-specific stem cells, which have great potential to be used in cell-based therapies. Here we provide an overview of its roles in regulating stem cells in epithelial tissues and its potential implications in related cancers.
在过去十年中，对河马信号通路的研究发现了一个复杂的信号网络，该网络整合了各种信号通路，以调节组织稳态、器官大小控制、组织修复和再生。河马信号通路的功能失调与肿瘤和癌症的发生有关。此外，有人提出河马信号通路在多种生物体的众多干细胞中发挥作用。最近，人们更加关注河马信号通路在组织特异性干细胞中的功能，这些干细胞在基于细胞的治疗中具有巨大的应用潜力。在这里，我们概述了它在调节上皮组织干细胞中的作用及其在相关癌症中的潜在影响。
