Ballázs Christina, Akhyari Payam, Mehdiani Arash, Kamiya Hiroyuki, Reinecke Petra, Felsberg Jörg, Saeed Diyar, Lichtenberg Artur, Boeken Udo
From the 1Department of Cardiovascular Surgery, Heinrich Heine University, Düsseldorf, Germany.
Exp Clin Transplant. 2016 Jun;14(3):349-52. doi: 10.6002/ect.2014.0115. Epub 2014 Dec 4.
Invasive fungal infection after solid-organ transplantation is known as a severe complication and carries with it a high risk of infection-related mortality. Among patients after heart transplant Aspergillus species most often cause atypical pneumonia. The incidence of invasive aspergillosis after heart transplant has been reported from 3% to 14%. It is the opportunistic pathogen with the highest mortality, ranging from 50% to 80%. Prompt antifungal therapy is crucial, but rapid diagnostic procedures with sufficient sensitivity and specificity are lacking at the moment. We present a rare case of a patient with massive metastasizing invasive aspergillosis within 1 month after heart transplant, undetected before death.
实体器官移植后的侵袭性真菌感染是一种严重并发症，且伴有较高的感染相关死亡率风险。在心脏移植后的患者中，曲霉菌属最常引发非典型肺炎。心脏移植后侵袭性曲霉病的发病率据报道在3%至14%之间。它是死亡率最高的机会致病菌，死亡率在50%至80%之间。及时的抗真菌治疗至关重要，但目前缺乏具有足够敏感性和特异性的快速诊断程序。我们报告了一例罕见病例，一名患者在心脏移植后1个月内发生大量转移性侵袭性曲霉病，生前未被检测到。
