Zbinden A, Imhof A, Wilhelm M J, Ruschitzka F, Wild P, Bloemberg G V, Mueller N J
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Transpl Infect Dis. 2012 Oct;14(5):E60-3. doi: 10.1111/j.1399-3062.2012.00779.x. Epub 2012 Sep 19.
Opportunistic invasive fungal infections are a major cause of mortality in immunocompromised patients. Early diagnosis of invasive aspergillosis and proper identification of the causative agent is crucial for guidance of therapy. Accurate differentiation of Aspergillus lentulus, a filamentous fungus often misidentified as atypical Aspergillus fumigatus, is of concern as multiple antifungal drugs show a reduced susceptibility. This is the first report, to our knowledge, of a proven pulmonary invasive fungal infection caused by A. lentulus after heart transplantation.
机会性侵袭性真菌感染是免疫功能低下患者死亡的主要原因。侵袭性曲霉病的早期诊断和致病病原体的正确鉴定对于指导治疗至关重要。慢生曲霉是一种常被误鉴定为非典型烟曲霉的丝状真菌，由于多种抗真菌药物对其敏感性降低，准确鉴别慢生曲霉备受关注。据我们所知，这是首例经证实的心脏移植后由慢生曲霉引起的肺部侵袭性真菌感染报告。
