设计的超分子丝状肽：纳米结构、细胞毒性和抗菌活性的平衡
Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity.
作者信息
Xu Dawei, Jiang Linhai, Singh Anju, Dustin Derek, Yang Miao, Liu Ling, Lund Reidar, Sellati Timothy J, Dong He
机构信息
Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA.
出版信息
Chem Commun (Camb). 2015 Jan 25;51(7):1289-92. doi: 10.1039/c4cc08808e.
Abstract
This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.
摘要
这项工作展示了一种设计策略，用于优化抗菌肽，使其在最小细胞毒性、增强稳定性、强大细胞穿透能力和有效抗菌活性之间达到理想平衡，这对于治疗细胞内微生物感染以及潜在的全身抗感染治疗具有巨大前景。
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