Liu Xiguang, Zhang Hongjun, Yu Xiaoyun, Song Tingting, Huang Peng, Wang Haichao, Song Shan-Ai
Department of Oncology, Affiliated Hospitals of Qingdao Medical College, Qingdao University, PR China.
Contemp Oncol (Pozn). 2014;18(5):334-9. doi: 10.5114/wo.2014.45308. Epub 2014 Nov 5.
To explore the correlation of the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) with maximum standardised uptake value (SUVmax) of (18)FDG-PET-CT in non-small cell lung cancer (NSCLC).
Thirty patients received PET-CT imaging protocol first, and then all the patients underwent needle biopsy though CT guidance. The tumour tissue of each patient was taken from two biopsy areas: one area was SUVmax = 2.5-5, and the other was SUVmax > 5. Expression of VEGF and EGFR were detected and analysed by immunohistochemical staining.
The expressions of both VEGF and EGFR had no statistically significant correlation with SUVmax in age, gender, pathology, or differentiation (p > 0.05). The expressions of both VEGF and EGFR had statistically significant correllation with SUVmax in tumour size and clinical stage (p < 0.05). SUVmax correlated positively with VEGF and EGFR expressions (r = 0.879, p < 0.05).
SUVmax correlated positively with expressions of VEGF and EGFR (r = 0.879, p = 0.000; r = 0.839, and p = 0.000, respectively). This study may provide guidance for radiotherapy of NSCLC.
探讨血管内皮生长因子（VEGF）和表皮生长因子受体（EGFR）的表达与非小细胞肺癌（NSCLC）中（18）FDG - PET - CT最大标准化摄取值（SUVmax）之间的相关性。
30例患者先接受PET - CT成像检查，然后所有患者在CT引导下进行穿刺活检。每位患者的肿瘤组织取自两个活检区域：一个区域的SUVmax = 2.5 - 5，另一个区域的SUVmax > 5。通过免疫组织化学染色检测并分析VEGF和EGFR的表达。
VEGF和EGFR的表达在年龄、性别、病理类型或分化程度方面与SUVmax均无统计学显著相关性（p > 0.05）。VEGF和EGFR的表达在肿瘤大小和临床分期方面与SUVmax均有统计学显著相关性（p < 0.05）。SUVmax与VEGF和EGFR的表达呈正相关（r = 0.879，p < 0.05）。
SUVmax与VEGF和EGFR的表达呈正相关（分别为r = 0.879，p = 0.000；r = 0.839，p = 0.000）。本研究可为NSCLC的放射治疗提供指导。
