• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The role of microglia in mediating the effect of the environment in brain plasticity and behavior.

作者信息

Branchi Igor, Alboni Silvia, Maggi Laura

机构信息

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità Rome, Italy.

Department of Life Sciences, University of Modena and Reggio Emilia Modena, Italy.

出版信息

Front Cell Neurosci. 2014 Nov 18;8:390. doi: 10.3389/fncel.2014.00390. eCollection 2014.

DOI:10.3389/fncel.2014.00390
PMID:25477783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4235360/
Abstract
摘要

相似文献

1
The role of microglia in mediating the effect of the environment in brain plasticity and behavior.小胶质细胞在介导环境对大脑可塑性和行为的影响中的作用。
Front Cell Neurosci. 2014 Nov 18;8:390. doi: 10.3389/fncel.2014.00390. eCollection 2014.
2
Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress.Fractalkine 受体缺陷可损害小胶质细胞和神经元对慢性应激的反应性。
Brain Behav Immun. 2016 Jul;55:114-125. doi: 10.1016/j.bbi.2015.07.024. Epub 2015 Jul 29.
3
Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior.丰富环境通过脂联素依赖的机制减少小胶质细胞和脑巨噬细胞的炎症表型：与抑郁样行为相关。
Brain Behav Immun. 2015 Nov;50:275-287. doi: 10.1016/j.bbi.2015.07.018. Epub 2015 Jul 22.
4
[Astrocytes and microglia: active players in synaptic plasticity].[星形胶质细胞与小胶质细胞：突触可塑性中的活跃参与者]
Med Sci (Paris). 2017 Dec;33(12):1071-1078. doi: 10.1051/medsci/20173312014. Epub 2017 Dec 20.
5
Microglia in neuronal plasticity: Influence of stress.小胶质细胞在神经元可塑性中的作用：应激的影响。
Neuropharmacology. 2015 Sep;96(Pt A):19-28. doi: 10.1016/j.neuropharm.2014.12.034. Epub 2015 Jan 9.
6
Genetic deletion of P-glycoprotein alters stress responsivity and increases depression-like behavior, social withdrawal and microglial activation in the hippocampus of female mice.基因敲除 P-糖蛋白会改变应激反应性，并增加雌性小鼠海马体中的抑郁样行为、社交回避和小胶质细胞激活。
Brain Behav Immun. 2017 Oct;65:251-261. doi: 10.1016/j.bbi.2017.05.008. Epub 2017 May 10.
7
Microglia: Dynamic Mediators of Synapse Development and Plasticity.小胶质细胞：突触发育和可塑性的动态调节因子
Trends Immunol. 2015 Oct;36(10):605-613. doi: 10.1016/j.it.2015.08.008.
8
Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis.生活方式塑造环境、小胶质细胞和成年神经发生之间的对话。
ACS Chem Neurosci. 2016 Apr 20;7(4):442-53. doi: 10.1021/acschemneuro.6b00009. Epub 2016 Mar 22.
9
Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.小胶质细胞和外周单核细胞之间的动态串扰是应激诱导的神经炎症和行为后果的基础。
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt A):40-48. doi: 10.1016/j.pnpbp.2016.04.013. Epub 2016 May 3.
10
Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice.小胶质细胞和神经元 IKKβ 对清醒行为小鼠突触可塑性和联想学习的差异贡献。
Glia. 2015 Apr;63(4):549-66. doi: 10.1002/glia.22756. Epub 2014 Oct 9.

引用本文的文献

1
Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health.摆脱抑郁症的炎症陷阱：调节免疫激活与可塑性之间的相互作用以促进心理健康。
Neurosci Appl. 2023 Nov 8;3:103923. doi: 10.1016/j.nsa.2023.103923. eCollection 2024.
2
Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress.白细胞介素18与大脑：应激期间的神经元功能、神经元存活及神经心理免疫学
Mol Psychiatry. 2025 Mar 22. doi: 10.1038/s41380-025-02951-z.
3
Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human.

本文引用的文献

1
Never-resting microglia: physiological roles in the healthy brain and pathological implications.永不停歇的小胶质细胞：在健康大脑中的生理作用及病理意义
Front Cell Neurosci. 2014 Aug 15;8:240. doi: 10.3389/fncel.2014.00240. eCollection 2014.
2
Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis.小胶质细胞及其 CX3CR1 信号通路参与海马体相关的记忆和神经发生，而非嗅球相关的记忆和神经发生。
Brain Behav Immun. 2014 Oct;41:239-50. doi: 10.1016/j.bbi.2014.04.009. Epub 2014 Jun 13.
3
Inflammation: a mechanism of depression?
P2X7 受体调控小胶质细胞功能：在大鼠、小鼠和人类中的研究。
Cells. 2024 Jan 16;13(2):161. doi: 10.3390/cells13020161.
4
Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions.海马体纵轴上的小胶质细胞多样性影响成年雄性小鼠在稳态条件下的突触可塑性。
J Neuroinflammation. 2022 Dec 8;19(1):292. doi: 10.1186/s12974-022-02655-z.
5
Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice.选择性 5-羟色胺再摄取抑制剂与炎症性肠病；是有益还是弊端？
Front Immunol. 2022 Oct 6;13:980189. doi: 10.3389/fimmu.2022.980189. eCollection 2022.
6
Work hard, play hard: how sexually differentiated microglia work to shape social play and reproductive behavior.努力工作，尽情玩耍：性别分化的小胶质细胞如何塑造社交玩耍和生殖行为。
Front Behav Neurosci. 2022 Sep 12;16:989011. doi: 10.3389/fnbeh.2022.989011. eCollection 2022.
7
Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade.伏硫西汀可预防脂多糖诱导的记忆损伤，而不抑制初始炎症级联反应。
Front Pharmacol. 2021 Feb 4;11:603979. doi: 10.3389/fphar.2020.603979. eCollection 2020.
8
Exercise, microglia, and beyond - workout to communicate with microglia.运动、小胶质细胞及其他——通过锻炼与小胶质细胞交流。
Neural Regen Res. 2020 Nov;15(11):2029-2030. doi: 10.4103/1673-5374.282241.
9
Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype.白细胞介素-10的缺失促进小胶质细胞向M1表型分化。
Front Cell Neurosci. 2019 Oct 9;13:430. doi: 10.3389/fncel.2019.00430. eCollection 2019.
10
The "systems approach" to treating the brain: opportunities in developmental psychopharmacology
.治疗大脑的“系统方法”：发育心理药理学中的机遇
Dialogues Clin Neurosci. 2019;21(2):211-215. doi: 10.31887/DCNS.2019.21.2/lloiacono.
炎症：抑郁的一种机制？
Neurosci Bull. 2014 Jun;30(3):515-23. doi: 10.1007/s12264-013-1439-3. Epub 2014 May 16.
4
Immunology of major depression.重度抑郁症的免疫学。
Neuroimmunomodulation. 2014;21(2-3):123-30. doi: 10.1159/000356540. Epub 2014 Feb 14.
5
Microglia and synapse: interactions in health and neurodegeneration.小胶质细胞与突触：健康与神经退行性变中的相互作用
Neural Plast. 2013;2013:425845. doi: 10.1155/2013/425845. Epub 2013 Dec 11.
6
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.小胶质细胞通过脑源性神经营养因子促进学习相关的突触形成。
Cell. 2013 Dec 19;155(7):1596-609. doi: 10.1016/j.cell.2013.11.030.
7
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis.动态的小胶质细胞改变是应激诱导的抑郁样行为和神经发生抑制的基础。
Mol Psychiatry. 2014 Jun;19(6):699-709. doi: 10.1038/mp.2013.155. Epub 2013 Dec 17.
8
Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus.慢性抗抑郁药物治疗导致大鼠下丘脑参与炎症反应的基因表达发生改变。
Eur J Pharmacol. 2013 Dec 5;721(1-3):158-67. doi: 10.1016/j.ejphar.2013.08.046. Epub 2013 Sep 25.
9
Factors regulating microglia activation.调控小胶质细胞激活的因素。
Front Cell Neurosci. 2013 Apr 23;7:44. doi: 10.3389/fncel.2013.00044. eCollection 2013.
10
Immune-neural connections: how the immune system's response to infectious agents influences behavior.免疫神经连接：免疫系统对感染因子的反应如何影响行为。
J Exp Biol. 2013 Jan 1;216(Pt 1):84-98. doi: 10.1242/jeb.073411.