Mandal Soham, Hepp Alexander, Müller Jens
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstr. 28/30, 48149 Münster, Germany.
Dalton Trans. 2015 Feb 28;44(8):3540-3. doi: 10.1039/c4dt02663b.
The DNA lesion 1,N(6)-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA : εA mispair readily forms doubly silver(I)-mediated base pairs εA-Ag(I)2-εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
针对DNA损伤1,N(6)-乙烯腺嘌呤（εA）的金属结合特性进行了研究。一种包含εA:εA错配的合成DNA双链体很容易形成双银（I）介导的碱基对εA-Ag（I）2-εA，这是嘌呤衍生物的双核金属介导同型碱基对的首个实例。它也是B-DNA双链体内Hoogsteen型金属介导同型碱基对的首个实例。
