Department of Chemistry, University of Turku, Vatselankatu 2, 20014, Turku, Finland.
Chembiochem. 2021 May 14;22(10):1733-1739. doi: 10.1002/cbic.202000821. Epub 2021 Feb 16.
Synthetic efforts towards nucleosides, nucleotides, oligonucleotides and nucleic acids covalently mercurated at one or more of their base moieties are summarized, followed by a discussion of the proposed, realized and abandoned applications of this unique class of compounds. Special emphasis is given to fields in which active research is ongoing, notably the use of Hg -mediated base pairing to improve the hybridization properties of oligonucleotide probes. Finally, this minireview attempts to anticipate potential future applications of organomercury nucleic acids.
总结了在核苷、核苷酸、寡核苷酸和核酸的碱基部分共价键合汞的合成工作，接着讨论了该独特类化合物的提议、实现和放弃的应用。特别强调了正在积极研究的领域，特别是利用 Hg 介导的碱基配对来改善寡核苷酸探针的杂交性质。最后，本综述尝试预测有机汞核酸的潜在未来应用。
