Moyer Caitlin E, Shelton Micah A, Sweet Robert A
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA.
Neurosci Lett. 2015 Aug 5;601:46-53. doi: 10.1016/j.neulet.2014.11.042. Epub 2014 Dec 3.
Schizophrenia is a chronic illness affecting approximately 0.5-1% of the world's population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal neuron dendritic morphology in multiple regions of the cerebral cortex. In this review, we summarize the evidence of reduced dendritic spine density and other dendritic abnormalities in schizophrenia, evaluate current data that informs the neurodevelopment timing of these impairments, and discuss what is known about possible upstream sources of dendritic spine loss in this illness.
精神分裂症是一种慢性疾病，影响着全球约0.5%-1%的人口。精神分裂症的病因复杂，包括多个基因以及对神经发育产生不利影响的环境因素。然而，许多精神分裂症患者的一个共同最终结果是大脑皮层多个区域的锥体神经元树突形态受损。在这篇综述中，我们总结了精神分裂症中树突棘密度降低和其他树突异常的证据，评估了有关这些损伤神经发育时间的现有数据，并讨论了关于该疾病中树突棘丢失可能的上游来源的已知情况。
