Machii K, Otsuka Y, Iwai H, Ueda K
Department of Veterinary Public Health, Institute of Public Health, Tokyo, Japan.
Lab Anim Sci. 1989 Jul;39(4):334-7.
Rabbits were either inoculated with Sendai virus (SV), strain MN, or caged with virus-inoculated rabbits on the same day of the viral inoculation, and examined for viral shedding and detection of viral antigens in the respiratory tract, histopathologic changes, and serum antibodies. Infectious virus was recovered from nasal swabs at postinoculation day (PID) 3 and disappeared by PID 10. Viral antigens were detected by immunofluorescence in epithelial cells of the nasal cavities, but not of the trachea and lungs from PID 3 to PID 10, and antibodies were detected after PID 7. Rabbits had no clinical manifestations and only exhibited a moderate increase in goblet cells of the nasal epithelium. In the transmission study, virus was recovered from one of three uninoculated rabbits at postexposure day (PED) 10 and antibodies were detected at PED 15 in the same rabbit. These data suggest that, although viral multiplication was limited to the nasal epithelium, laboratory rabbits are susceptible to Sendai virus infection.
兔子要么接种仙台病毒（SV）MN株，要么在病毒接种当天与接种病毒的兔子关在同一个笼子里，并检测其呼吸道的病毒排出和病毒抗原、组织病理学变化以及血清抗体。接种后第3天（PID 3）从鼻拭子中检测到传染性病毒，到PID 10时消失。在PID 3至PID 10期间，通过免疫荧光在鼻腔上皮细胞中检测到病毒抗原，但在气管和肺中未检测到，并且在PID 7之后检测到抗体。兔子没有临床表现，仅表现出鼻腔上皮杯状细胞适度增加。在传播研究中，在暴露后第10天（PED 10）从三只未接种的兔子中的一只体内检测到病毒，并且在同一兔子的PED 15检测到抗体。这些数据表明，尽管病毒增殖仅限于鼻腔上皮，但实验兔对仙台病毒感染易感。
