Carrano V A, Barthold S W, Beck D S, Smith A L
Lab Anim Sci. 1984 Dec;34(6):573-6.
Pre-infection with mouse hepatitis virus (MHV) strains S, 3, or JHM reduced the ability of mice to seroconvert to PVM. Geometric mean antibody titers to PVM among MHV pre-infected mice were lower than those for control mice given only PVM, and dually infected mice seroconverted to PVM later than mice given PVM alone. PVM was not recovered from normally permissive respiratory tract tissues of MHV-S pre-infected mice. Pre-infection of DBA/2 mice with MHV-S compromised the susceptibility of these mice to lethal Sendai virus infection but did not substantially reduce the titers of infectious Sendai virus recovered from the lungs. Serologic responses to Sendai virus and lung Sendai virus titers were similar in Sendai virus-resistant C57BL/6 mice pre-infected or not with MHV-S.
用小鼠肝炎病毒（MHV）S株、3株或JHM株进行感染前处理，会降低小鼠对仙台病毒（PVM）产生血清转化的能力。在MHV预感染小鼠中，针对PVM的几何平均抗体滴度低于仅给予PVM的对照小鼠，并且双重感染的小鼠比单独给予PVM的小鼠更晚对PVM产生血清转化。在MHV-S预感染小鼠的正常允许性呼吸道组织中未检测到PVM。用MHV-S对DBA/2小鼠进行感染前处理会损害这些小鼠对致死性仙台病毒感染的易感性，但不会显著降低从肺中回收的传染性仙台病毒的滴度。在预先感染或未预先感染MHV-S的抗仙台病毒C57BL/6小鼠中，对仙台病毒的血清学反应和肺仙台病毒滴度相似。
