Niu Xiang-Ke, Bhetuwal Anup, Das Sushant, Xiao Ying-Quan, Sun Feng, Zeng Li-Chuan, Yang Han-Feng
Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu, 610000, China.
Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Dec;34(6):950-956. doi: 10.1007/s11596-014-1379-9. Epub 2014 Dec 6.
There have been numerous studies done to explore the diagnostic performance of quantitative diffusion-weighted (DW) MR imaging to differentiate between benign and malignant pancreatic masses. However, the results have been inconsistent. We performed a meta-analysis to investigate whether DW-MR imaging can differentiate between these two diseases. Databases including MEDLINE, EMBASE and Cochrane Library were utilized to find relevant articles published between January 2001 and January 2014. A Stata version 12.0 and a Meta-Disc version 1.4 were used to describe primary results. Twelve studies with 594 patients, which fulfilled the inclusion criteria, were enrolled for the analysis. The pooled sensitivity and specificity of DW imaging was 0.91 (95% CI: 0.84, 0.95) and 0.86 (95% CI: 0.76, 0.93) respectively. The area under the curve of the summary receiver operating characteristic was 0.95 (95% CI: 0.93, 0.96). The results indicated that DW imaging might be a valuable tool for differentiating benign and malignant pancreatic masses.
已经进行了大量研究来探索定量扩散加权磁共振成像（DW-MR成像）在鉴别胰腺良性和恶性肿块方面的诊断性能。然而，结果并不一致。我们进行了一项荟萃分析，以研究DW-MR成像是否能够区分这两种疾病。利用包括医学文献数据库（MEDLINE）、荷兰医学文摘数据库（EMBASE）和考科蓝图书馆在内的数据库，查找2001年1月至2014年1月期间发表的相关文章。使用Stata 12.0版和Meta-Disc 1.4版来描述主要结果。纳入12项研究共594例患者进行分析，这些研究符合纳入标准。DW成像的合并敏感度和特异度分别为0.91（95%CI：0.84，0.95）和0.86（95%CI：0.76，0.93）。汇总的受试者工作特征曲线下面积为0.95（95%CI：0.93，0.96）。结果表明，DW成像可能是鉴别胰腺良性和恶性肿块的一种有价值的工具。
