Yu Xiao-Ping, Wen Lu, Hou Jing, Wang Hui, Lu Qiang
Department of Diagnostic Radiology, Hunan Cancer Hospital & Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China.
J Huazhong Univ Sci Technolog Med Sci. 2016 Aug;36(4):594-600. doi: 10.1007/s11596-016-1631-6. Epub 2016 Jul 28.
Preoperative detection of lymph nodes (LNs) metastasis is always highly challenging for radiologists nowadays. The utility of quantitative dynamic contrast-enhanced magnetic resonance imaging (QDCE-MRI) in identifying LNs metastasis is not well understood. In the present study, 59 patients with histologically proven rectal carcinoma underwent preoperative QDCE-MRI. The short axis diameter ratio, long axis diameter ratio, short-to-long axis diameter ratio and QDEC-MRI parameters (K(trans), Kep, fPV and Ve) values were compared between the non-metastatic (n=44) and metastatic (n=35) LNs groups based on pathological examination. Compared with the non-metastatic group, the metastatic group exhibited significantly higher short axis diameter (7.558±0.668 mm vs. 5.427±0.285 mm), K(trans) (0.483±0.198 min(-1) vs. 0.218±0.116 min(-1)) and Ve (0.399±0.118 vs. 0.203±0.096) values (all P<0.05). The short-to-long axis diameter ratio, long axis diameter ratio, Kep and fPV values did not show significant differences between the two groups. In conclusion, our results showed that for LNs larger than 5 mm in rectal cancer, there are distinctive differences in the K(trans) and Ve values between the metastatic and non-metastatic LNs, suggesting that QDCE-MRI may be potentially helpful in identifying LNs status.
目前，术前检测淋巴结（LN）转移对放射科医生来说始终极具挑战性。定量动态对比增强磁共振成像（QDCE-MRI）在识别LN转移方面的效用尚未得到充分了解。在本研究中，59例经组织学证实的直肠癌患者接受了术前QDCE-MRI检查。基于病理检查，比较了非转移组（n = 44）和转移组（n = 35）LN的短轴直径比、长轴直径比、短轴与长轴直径比以及QDCE-MRI参数（Ktrans、Kep、fPV和Ve）值。与非转移组相比，转移组的短轴直径（7.558±0.668 mm对5.427±0.285 mm）、Ktrans（0.483±0.198 min-1对0.218±0.116 min-1）和Ve（0.399±0.118对0.203±0.096）值均显著更高（所有P<0.05）。两组之间的短轴与长轴直径比、长轴直径比、Kep和fPV值无显著差异。总之，我们的结果表明，对于直肠癌中直径大于5 mm的LN，转移和非转移LN的Ktrans和Ve值存在明显差异，这表明QDCE-MRI可能有助于识别LN状态。
