Scheller M S, Zornow M H, Fleischer J E, Shearman G T, Greber T F
Department of Anesthesiology, University of California San Diego, La Jolla 92093.
Neuropharmacology. 1989 Jul;28(7):677-81. doi: 10.1016/0028-3908(89)90150-0.
Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.
用挥发性麻醉剂麻醉的兔子被给予大剂量的N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801。在观察并记录MK-801的血流动力学和脑电图效应后，测试这些动物对挥发性麻醉剂的需求，以防止对有害刺激产生运动反应。结果表明，MK-801以剂量依赖性方式显著降低麻醉需求，同时还以与产生更深麻醉平面相一致的方式影响血流动力学和脑电图。
