Wyman Peter A, Henry David, Knoblauch Shannon, Brown C Hendricks
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
University of Illinois at Chicago, Chicago, IL, USA.
Prev Sci. 2015 Oct;16(7):956-66. doi: 10.1007/s11121-014-0535-6.
The dynamic wait-listed design (DWLD) and regression point displacement design (RPDD) address several challenges in evaluating group-based interventions when there is a limited number of groups. Both DWLD and RPDD utilize efficiencies that increase statistical power and can enhance balance between community needs and research priorities. The DWLD blocks on more time units than traditional wait-listed designs, thereby increasing the proportion of a study period during which intervention and control conditions can be compared, and can also improve logistics of implementing intervention across multiple sites and strengthen fidelity. We discuss DWLDs in the larger context of roll-out randomized designs and compare it with its cousin the Stepped Wedge design. The RPDD uses archival data on the population of settings from which intervention unit(s) are selected to create expected posttest scores for units receiving intervention, to which actual posttest scores are compared. High pretest-posttest correlations give the RPDD statistical power for assessing intervention impact even when one or a few settings receive intervention. RPDD works best when archival data are available over a number of years prior to and following intervention. If intervention units were not randomly selected, propensity scores can be used to control for non-random selection factors. Examples are provided of the DWLD and RPDD used to evaluate, respectively, suicide prevention training (QPR) in 32 schools and a violence prevention program (CeaseFire) in two Chicago police districts over a 10-year period. How DWLD and RPDD address common threats to internal and external validity, as well as their limitations, are discussed.
动态候补名单设计(DWLD)和回归点位移设计(RPDD)解决了在评估基于组的干预措施时,由于组数量有限而面临的几个挑战。DWLD和RPDD都利用了提高统计功效的效率,并且可以增强社区需求与研究重点之间的平衡。与传统的候补名单设计相比,DWLD在更多的时间单位上进行分组,从而增加了可以比较干预组和对照组情况的研究周期比例,还可以改善在多个地点实施干预的后勤工作,并提高干预的保真度。我们在更广泛的推出随机设计背景下讨论DWLD,并将其与其同类的阶梯楔形设计进行比较。RPDD使用从其中选择干预单位的设置总体的存档数据,为接受干预的单位创建预期的后测分数,并将其与实际后测分数进行比较。即使只有一个或几个设置接受干预,较高的前测-后测相关性也赋予了RPDD评估干预效果的统计功效。当在干预前后的若干年都有存档数据时,RPDD的效果最佳。如果干预单位不是随机选择的,可以使用倾向得分来控制非随机选择因素。文中提供了分别使用DWLD和RPDD评估32所学校的自杀预防培训(QPR)以及在芝加哥两个警察辖区为期10年的暴力预防计划(CeaseFire)的示例。文中还讨论了DWLD和RPDD如何应对内部和外部效度的常见威胁以及它们的局限性。