应激颗粒、P小体与癌症
Stress granules, P-bodies and cancer.
作者信息
Anderson Paul, Kedersha Nancy, Ivanov Pavel
机构信息
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Biochim Biophys Acta. 2015 Jul;1849(7):861-70. doi: 10.1016/j.bbagrm.2014.11.009. Epub 2014 Dec 5.
Abstract
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic machinery, and stress response programs. This review examines evidence implicating RNA granules in the pathogenesis of cancer and discusses their potential as targets for anticancer therapies. This article is part of a Special Issue entitled: Translation and Cancer.
摘要
癌细胞暴露于肿瘤微环境中的不利条件下，并利用转录后控制机制以增强细胞存活的方式重新编程基因表达。应激颗粒和加工体是含RNA的颗粒，它们通过调节细胞信号通路、代谢机制和应激反应程序来促进这一过程。本综述研究了涉及RNA颗粒在癌症发病机制中的证据，并讨论了它们作为抗癌治疗靶点的潜力。本文是名为“翻译与癌症”的特刊的一部分。
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