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采用等离子体离子注入增强化学气相沉积(PIRAC)渗氮技术制备的氮化钛涂层Ti-6Al-4V合金植入物的骨整合:大鼠长期时间进程研究

Osseointegration of Ti-6Al-4V alloy implants with a titanium nitride coating produced by a PIRAC nitriding technique: a long-term time course study in the rat.

作者信息

Sovak Guy, Gotman Irena, Weiss Anna

机构信息

1Department of Anatomy,Canadian Memorial Chiropractic College,Toronto,ON M2H 3J1,Canada.

2The Faculty of Materials Engineering,Technion-Israel Institute of Technology,Haifa 31096,Israel.

出版信息

Microsc Microanal. 2015 Feb;21(1):179-89. doi: 10.1017/S1431927614013634. Epub 2014 Dec 8.

Abstract

This study examined bone tissue responses to Ti-6Al-4V alloy implants with a hard TiN coating applied by an original powder immersion reaction-assisted coating (PIRAC) nitriding method. Progression of implant fixation in the distal epiphysis and within the medullary cavity of the rat femur was evaluated between 3 days and 6 months postimplantation by scanning electron microscopy, oxytetracycline incorporation, and histochemistry. After 6 months, successful osseointegration was achieved in both epiphyseal and diaphyseal sites. Throughout, implant portions located within the epiphysis remained in close contact with bone trabeculae that gradually engulfed the implant forming a bone collar continuous with the trabecular network of the epiphysis. In the diaphysis, woven bone was first formed within the marrow cavity around the implant and later was replaced by a shell of compact bone around the implant. In general, higher osseointegration rates were measured for TiN-coated versus the uncoated implants, both in the epiphysis and in the diaphysis. In conclusion, our findings indicate an excellent long-term biocompatibility of TiN coatings applied by the PIRAC nitriding technique and superior osteoinductive ability in comparison with uncoated Ti-6Al-4V alloy. Such coatings can, therefore, be considered for improving the corrosion and wear resistance of titanium-based orthopedic implants.

摘要

本研究考察了通过原始的粉末浸没反应辅助涂层(PIRAC)氮化法施加硬氮化钛(TiN)涂层的Ti-6Al-4V合金植入物的骨组织反应。通过扫描电子显微镜、土霉素掺入和组织化学评估植入大鼠股骨远端骨骺和髓腔内的植入物在植入后3天至6个月期间的固定进展情况。6个月后,骨骺和骨干部位均实现了成功的骨整合。在整个过程中,位于骨骺内的植入物部分始终与骨小梁紧密接触,骨小梁逐渐包裹植入物,形成与骨骺小梁网络连续的骨环。在骨干中,编织骨首先在植入物周围的骨髓腔内形成,随后被植入物周围的致密骨壳所取代。总体而言,无论是在骨骺还是骨干中,TiN涂层植入物的骨整合率均高于未涂层植入物。总之,我们的研究结果表明,通过PIRAC氮化技术施加的TiN涂层具有出色的长期生物相容性,与未涂层的Ti-6Al-4V合金相比,具有卓越的骨诱导能力。因此,此类涂层可用于提高钛基骨科植入物的耐腐蚀性和耐磨性。

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