用于预防婴幼儿轮状病毒腹泻的轮状病毒疫苗的发展前景。

Prospects for development of a rotavirus vaccine against rotavirus diarrhea in infants and young children.

作者信息

Kapikian A Z, Flores J, Hoshino Y, Midthun K, Gorziglia M, Green K Y, Chanock R M, Potash L, Sears S D, Clements M L

机构信息

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

出版信息

Rev Infect Dis. 1989 May-Jun;11 Suppl 3:S539-46. doi: 10.1093/clinids/11.supplement_3.s539.

DOI:10.1093/clinids/11.supplement_3.s539

PMID:2548276

Abstract

Major advances have been made in elucidating the etiologic agents of severe infantile diarrhea, and it is clear that rotaviruses are the single most important etiologic agents. Progress in the development of rotavirus vaccine candidates has also moved swiftly with the "Jennerian" approach, in which a related live, attenuated rotavirus strain from a nonhuman host is used as the immunizing antigen. If this strategy is not effective against all rotavirus serotypes, reassortant rotaviruses hold great promise for the development of a multivalent vaccine. Field trials with the "Jennerian" approach vaccines are under way, and phase 1 trials with the reassortants have been initiated.

摘要

在阐明重症婴幼儿腹泻的病原体方面已取得重大进展，很明显轮状病毒是最重要的单一病原体。轮状病毒候选疫苗的研发也通过“詹纳式”方法迅速推进，即使用来自非人类宿主的相关活的减毒轮状病毒株作为免疫抗原。如果该策略对所有轮状病毒血清型无效，重配轮状病毒在多价疫苗的研发方面极具前景。采用“詹纳式”方法的疫苗正在进行现场试验，重配疫苗的1期试验也已启动。