Hamburg School of Food Science, Institute of Food Chemistry , Grindelallee 117, D-20146 Hamburg, Germany.
J Agric Food Chem. 2014 Dec 31;62(52):12487-90. doi: 10.1021/jf505056g. Epub 2014 Dec 17.
Cattle husbandry is a major contributor to atmospheric methane, which is considered as an important greenhouse gas. Moreover, the generation of methane in the intestine of domestic ruminants by methanogenic bacteria is a drag on feed efficacy. Studies on methanogenesis have typically implied model organisms that are, however, not relevant in the ruminant gut. This paper shows that methyl-CoM reductase catalyzing the final step of methanogenesis in Methanobrevibacter ruminantium, a major participant in methane production by cattle, is inhibited by 2-bromoethanesulfonate, a compound often used as a model in animal agriculture, with an apparent IC50 of 0.4 ± 0.04 μM.
畜牧业是大气甲烷的主要贡献者，甲烷被认为是一种重要的温室气体。此外，产甲烷菌在反刍动物肠道中产生的甲烷会降低饲料的效率。关于甲烷生成的研究通常暗示了模型生物，但这些模型生物与反刍动物肠道无关。本文表明，催化产甲烷菌 Methanobrevibacter ruminantium 中甲烷生成最后一步的甲基辅酶 M 还原酶被 2-溴乙磺酸盐抑制，2-溴乙磺酸盐是动物农业中常用的模型化合物，其表观 IC50 为 0.4 ± 0.04 μM。
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