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一项针对局限性前列腺癌男性及其女性伴侣的基于伴侣的性干预随机对照试验。

A randomised controlled trial of a couples-based sexuality intervention for men with localised prostate cancer and their female partners.

作者信息

Chambers Suzanne K, Occhipinti Stefano, Schover Leslie, Nielsen Lisa, Zajdlewicz Leah, Clutton Samantha, Halford Kim, Gardiner Robert A, Dunn Jeff

机构信息

School of Applied Psychology, Griffith University, Brisbane, Australia.

Cancer Council Queensland, Brisbane, Australia.

出版信息

Psychooncology. 2015 Jul;24(7):748-56. doi: 10.1002/pon.3726. Epub 2014 Dec 8.

Abstract

OBJECTIVE

The diagnosis and treatment of prostate cancer is followed by substantive sexual morbidity. The optimal approach for intervening remains unclear.

METHODS/DESIGN: A three-arm randomised control trial was undertaken with 189 heterosexual couples where the man had been diagnosed with prostate cancer and treated surgically. The efficacy of peer-delivered telephone support versus nurse-delivered telephone counselling versus usual care in improving both men's and women's sexual adjustment was investigated. Assessments were undertaken at baseline (pre-test) with follow-up at 3, 6 and 12 months.

RESULTS

At 12 months, men in the peer (p = 0.016) and nurse intervention (p = 0.008) were more likely to use medical treatments for erectile dysfunction (ED) than men in the usual care arm. Men in the nurse intervention more frequently used oral medication for ED than men in usual care (p = 0.002). No significant effects were found for sexual function, sexuality needs, sexual self-confidence, masculine self-esteem, marital satisfaction or intimacy.

CONCLUSION

Although peer and nurse couples-based interventions can increase use of medical treatments for ED, this may not translate into better sexual or relationship outcomes. More research is needed into the optimal timing of interventions to improve sexual outcomes for men with prostate cancer and to identify the subpopulations that will benefit from them.

摘要

目的

前列腺癌的诊断和治疗会伴随严重的性方面的不良后果。目前尚不清楚最佳的干预方法。

方法/设计:对189对异性恋夫妇进行了一项三臂随机对照试验,其中男性被诊断患有前列腺癌并接受了手术治疗。研究了同伴提供的电话支持、护士提供的电话咨询与常规护理相比,在改善男性和女性性适应方面的效果。在基线(预测试)时进行评估,并在3个月、6个月和12个月时进行随访。

结果

在12个月时,同伴干预组(p = 0.016)和护士干预组(p = 0.008)的男性比常规护理组的男性更有可能使用治疗勃起功能障碍(ED)的药物。护士干预组的男性比常规护理组的男性更频繁地使用口服药物治疗ED(p = 0.002)。在性功能、性需求、性自信、男性自尊、婚姻满意度或亲密关系方面未发现显著影响。

结论

虽然基于同伴和护士的夫妻干预可以增加治疗ED药物的使用,但这可能不会转化为更好的性或关系结果。需要更多的研究来确定改善前列腺癌男性性结果的干预的最佳时机,并确定将从中受益的亚人群。

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