Ma Hongen, Yang Yi, Li Yingna, Cariola Laura, Gillanders David
Health in Social Science, University of Edinburgh, Edinburgh, UK.
Department of Psychology, University of Edinburgh, Edinburgh, UK.
Psychooncology. 2025 Jan;34(1):e70080. doi: 10.1002/pon.70080.
There is an increasing amount of literature acknowledging the significance of addressing the psychosocial impact of prostate cancer (PCa) on couples' relationship functioning and well-being. However, research on developing and evaluating psychological interventions for individuals and couples coping with PCa remains limited. This systematic review aimed to critically evaluate and synthesise the effectiveness of psychological interventions in improving the relationship functioning of couples affected by PCa and to identify the moderating role of several methodological characteristics of intervention studies.
Five databases MEDLINE, PsycINFO, Embase, Global Health, and Cochrane Library were searched up to September 2024. Twenty-three studies with randomised trials and a total sample size of 3333 participants were included. Random effects meta-analyses for relationship functioning, sensitivity analysis for outliers, and publication bias analysis were conducted.
The results showed that psychological interventions had a non-significant trivial effect (g = 0.06, p = 0.328) on improving relationship functioning among couples coping with PCa. Subgroup analyses identified two potential moderators: firstly, the intervention format (conjoint vs. individual; p = 0.005), and secondly, the intervention frequency (session number < 6 vs. session number ≥ 6; p = 0.004).
The findings suggest that more high-quality intervention studies are needed to improve the relationship functioning of those affected by PCa, with screening processes to select more representative samples at entry. The implications for clinical practice highlight the need to tailor interventions to the specific needs of couples coping with PCa.
越来越多的文献认识到解决前列腺癌（PCa）对夫妻关系功能和幸福感的心理社会影响的重要性。然而，针对应对PCa的个体和夫妻开发和评估心理干预措施的研究仍然有限。本系统综述旨在批判性地评估和综合心理干预措施在改善受PCa影响的夫妻关系功能方面的有效性，并确定干预研究的几个方法学特征的调节作用。
截至2024年9月，对五个数据库MEDLINE、PsycINFO、Embase、全球健康和Cochrane图书馆进行了检索。纳入了23项随机试验研究，总样本量为3333名参与者。对关系功能进行随机效应荟萃分析，对异常值进行敏感性分析，并进行发表偏倚分析。
结果表明，心理干预在改善应对PCa的夫妻关系功能方面具有不显著的微小效应（g = 0.06，p = 0.328）。亚组分析确定了两个潜在的调节因素：首先是干预形式（联合干预与个体干预；p = 0.005），其次是干预频率（疗程数<6与疗程数≥6；p = 0.004）。
研究结果表明，需要更多高质量的干预研究来改善受PCa影响者的关系功能，在入组时要有筛选过程以选择更具代表性的样本。对临床实践的启示突出了根据应对PCa的夫妻的具体需求调整干预措施的必要性。
