Murata K, Nakagawa I, Kumeta Y, Kitahata L M, Collins J G
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Anesth Analg. 1989 Aug;69(2):185-91.
The analgesic effectiveness of perispinal clonidine administration prompted us to evaluate clonidine effects on spinal dorsal horn wide dynamic range neurons. Intrathecal clonidine produced a dose-dependent (10 and 30 micrograms), yohimbine-reversible suppression of noxiously evoked activity in decerebrate, spinal cord-transected cats. In addition, combining ineffective intrathecal doses of morphine (25 micrograms) and clonidine (5 micrograms) produced statistically significant, reversible suppression of noxiously evoked activity. The time course of suppression was similar to that observed behaviorally. These results support the role of spinal alpha 2-adrenergic receptors in clonidine analgesia.
椎旁注射可乐定的镇痛效果促使我们评估可乐定对脊髓背角广动力范围神经元的作用。鞘内注射可乐定可使去大脑、脊髓横断猫的伤害性诱发活动产生剂量依赖性（10和30微克）、育亨宾可逆性抑制。此外，联合使用无效剂量的鞘内吗啡（25微克）和可乐定（5微克）可产生具有统计学意义的、可逆性的伤害性诱发活动抑制。抑制的时间进程与行为学观察结果相似。这些结果支持脊髓α2-肾上腺素能受体在可乐定镇痛中的作用。
