Brock K V, Jones J B, Shull R M, Potgieter L N
Department of Pathobiology, University of Tennessee Veterinary Teaching Hospital, Knoxville 37901.
Am J Vet Res. 1989 Jun;50(6):965-9.
The effects of canine parvovirus (CPV) infection in dogs with hemolytic anemia was compared with the clinical effects of human parvovirus-induced aplastic anemia in human beings with chronic regenerative anemias. Phenylhydrazine was used to induce a transient, severe, hemolytic anemia in dogs to evaluate the effects of CPV infection on rapidly dividing bone marrow precursors. Erythrocyte colony-forming unit bone marrow cultures and cytologic examination of bone marrow were used to determine the effects of CPV infection on erythroid bone marrow precursors. The induced hemolytic anemia regenerated rapidly and although the bone marrow was infected, it was determined that CPV infection did not induce a detectable decrease in erythroid progenitors in dogs with severe hemolytic anemia.
将犬细小病毒（CPV）感染对患有溶血性贫血的犬的影响，与人类细小病毒诱导的再生障碍性贫血对患有慢性再生性贫血的人类的临床影响进行了比较。使用苯肼诱导犬出现短暂、严重的溶血性贫血，以评估CPV感染对快速分裂的骨髓前体细胞的影响。采用红细胞集落形成单位骨髓培养和骨髓细胞学检查来确定CPV感染对红系骨髓前体细胞的影响。诱导的溶血性贫血迅速再生，尽管骨髓受到感染，但已确定CPV感染并未导致严重溶血性贫血犬的红系祖细胞出现可检测到的减少。
