造血干细胞移植后一名儿科患者的BK病毒肾病
BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation.
作者信息
Aksenova M, Tsetlina V, Gutovskaya E, Mitrofanova A, Balashov D, Maschan A
机构信息
Nephrology Department, Research and Clinical Institute for Pediatrics, the Pirogov Russian National Research Medical University, Moscow, Russia; Department of Clinical Diagnostics, the Rogachev Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
出版信息
Pediatr Transplant. 2015 Feb;19(1):E29-32. doi: 10.1111/petr.12411. Epub 2014 Dec 7.
We report the case of a seven-yr-old Caucasian girl who presented with progressive deterioration of renal function 13 months after HSCT for myelodysplastic syndrome. BK virus nephropathy was suspected and confirmed. After reduction of immunosuppression and treatment with IVIG, leflunomide, ciprofloxacin, and cidofovir, clearance of BK virus from blood was achieved, and further progression or renal failure was prevented. We believe that BK virus nephropathy should be considered in cases of renal function deterioration in all immunocompromised patients.
我们报告了一名7岁白种女孩的病例，她在接受异基因造血干细胞移植治疗骨髓增生异常综合征13个月后出现肾功能进行性恶化。怀疑并确诊为BK病毒肾病。在减少免疫抑制并使用静脉注射免疫球蛋白、来氟米特、环丙沙星和西多福韦治疗后，血液中的BK病毒被清除，防止了病情进一步进展或肾衰竭。我们认为，所有免疫功能低下患者出现肾功能恶化时均应考虑BK病毒肾病。
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