Yu Yonghui, Chai Jiake
Department of Burn and Plastic Surgery, The First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China.
Int J Mol Med. 2015 Feb;35(2):305-10. doi: 10.3892/ijmm.2014.2023. Epub 2014 Dec 5.
Burns are common accidental injuries. The main clinical manifestations of severe burn injury are insulin resistance and high metabolism. Insulin resistance results in hyperglycemia, which may lead to skeletal muscle wasting and suspended wound healing. It also elevates the risk of infection and sepsis. Studies have indicated that insulin receptor (IR) and insulin receptor substrate 1 (IRS1) are essential factors involved in the regulation of blood glucose levels. Moreover, the suppression of the IR/IRS1 signaling pathway results in insulin resistance. Recent studies have also indicated that miRNAs, which are small non-coding RNAs consisting of 20-23 nucleotides, target the 3'-untranslated region (3'-UTR) of IRS1 mRNA and attenuate protein translation. miRNAs also play an important role in the development of type II diabetes (T2D) and obesity-induced insulin resistance. In the present review, we discuss the involvement of miRNAs in burn-induced insulin resistance through the targeting of the IR/IRS1 signaling pathway. We also discuss the possibility of miRNAs a novel therapeutic target in insulin resistance in burn patients.
烧伤是常见的意外伤害。严重烧伤的主要临床表现为胰岛素抵抗和高代谢。胰岛素抵抗会导致高血糖，这可能会导致骨骼肌萎缩和伤口愈合延迟。它还会增加感染和脓毒症的风险。研究表明，胰岛素受体（IR）和胰岛素受体底物1（IRS1）是参与调节血糖水平的关键因素。此外，IR/IRS1信号通路的抑制会导致胰岛素抵抗。最近的研究还表明，微小RNA（miRNA）是由20-23个核苷酸组成的小非编码RNA，靶向IRS1 mRNA的3'-非翻译区（3'-UTR）并减弱蛋白质翻译。miRNA在2型糖尿病（T2D）的发展和肥胖诱导的胰岛素抵抗中也起重要作用。在本综述中，我们讨论了miRNA通过靶向IR/IRS1信号通路参与烧伤诱导的胰岛素抵抗。我们还讨论了miRNA作为烧伤患者胰岛素抵抗新治疗靶点的可能性。
