Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, China.
J Genet Genomics. 2012 Jan;39(1):11-8. doi: 10.1016/j.jgg.2011.11.007. Epub 2011 Dec 29.
MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.
MicroRNAs 属于新发现的一类小非编码 RNA，广泛参与多种生理过程的微调，如 2 型糖尿病 (T2D) 和肥胖症的发病机制。微阵列研究强调了糖尿病和肥胖模型中胰岛素靶组织中 miRNA 表达谱的改变。新出现的证据表明，miRNAs 在胰岛素的产生、分泌和作用中以及在葡萄糖稳态和脂肪细胞分化的各个方面都发挥着重要作用。鉴定与 T2D 和肥胖相关的组织特异性 miRNAs 可能有助于未来开发有效的策略，用于肥胖相关医疗并发症的早期诊断和治疗干预。
