Ahmed Hafiz, Guha Prasun, Kaptan Engin, Bandyopadhyaya Gargi
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA ; University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, USA.
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Trends Carbohydr Res. 2011;3(2):13-22.
Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.
蛋白质-碳水化合物相互作用在调节细胞-细胞和细胞-细胞外基质相互作用中发挥着重要作用，而这些相互作用反过来又介导各种生物学过程，如生长调节、免疫功能、癌症转移和细胞凋亡。半乳糖凝集素-3是β-半乳糖苷结合蛋白家族的成员，具有多种功能，参与正常生长发育以及癌症进展和转移，但其功能的详细机制尚不清楚。本文综述了其结构、结合特性、转录调控以及在同型/异型细胞黏附、血管生成和细胞凋亡中的作用。
