Neurodegeneration in Huntington's disease involves loss of cystathionine γ-lyase.
作者信息
Paul Bindu D, Snyder Solomon H
机构信息
a The Solomon H Snyder Department of Neuroscience ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
出版信息
Cell Cycle. 2014;13(16):2491-3. doi: 10.4161/15384101.2014.950538.
Abstract
摘要
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Neurodegeneration in Huntington's disease involves loss of cystathionine γ-lyase.亨廷顿舞蹈病中的神经退行性变涉及胱硫醚γ-裂解酶的缺失。
Cell Cycle. 2014;13(16):2491-3. doi: 10.4161/15384101.2014.950538.
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Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes.晚期伤口修复过程中胱硫醚-γ-裂解酶（CSE）的增加：硫化氢在角质细胞中触发角蛋白 10 的表达。
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本文引用的文献
1
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease.胱硫醚γ-裂合酶缺乏介导亨廷顿病的神经退行性变。
Nature. 2014 May 1;509(7498):96-100. doi: 10.1038/nature13136. Epub 2014 Mar 26.
2
Sulfhydration mediates neuroprotective actions of parkin.巯基化介导帕金森蛋白的神经保护作用。
Nat Commun. 2013;4:1626. doi: 10.1038/ncomms2623.
3
Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2.硫化氢通过 Keap1 的 S-巯基化和 Nrf2 的激活来防止细胞衰老。
Antioxid Redox Signal. 2013 May 20;18(15):1906-19. doi: 10.1089/ars.2012.4645. Epub 2013 Feb 7.
4
H₂S signalling through protein sulfhydration and beyond.硫化氢通过蛋白质巯基化的信号转导及其他途径。
Nat Rev Mol Cell Biol. 2012 Jul 11;13(8):499-507. doi: 10.1038/nrm3391.
5
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.Rhes是一种纹状体特异性蛋白，介导突变型亨廷顿蛋白的细胞毒性。
Science. 2009 Jun 5;324(5932):1327-30. doi: 10.1126/science.1172871.
6
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.硫化氢作为一种生理性血管舒张剂：胱硫醚γ-裂解酶缺失小鼠的高血压
Science. 2008 Oct 24;322(5901):587-90. doi: 10.1126/science.1162667.
7
Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.半胱胺可提高亨廷顿舞蹈病转基因小鼠大脑以及聚谷氨酰胺聚集的PC12模型中的L-半胱氨酸水平。
J Neurochem. 2004 Oct;91(2):413-22. doi: 10.1111/j.1471-4159.2004.02726.x.
8
Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression.小鼠胱硫醚γ-裂解酶：完整的cDNA和基因组序列、启动子活性、组织分布及发育表达
Biochem J. 2004 Jul 1;381(Pt 1):113-23. doi: 10.1042/BJ20040243.
9
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.在亨廷顿病转基因模型中，通过给予转谷氨酰胺酶抑制剂胱胺，延长了生存期并减少了异常运动。
Nat Med. 2002 Feb;8(2):143-9. doi: 10.1038/nm0202-143.
10
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.
Hum Mol Genet. 2000 Nov 22;9(19):2799-809. doi: 10.1093/hmg/9.19.2799.
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