Beauchaine Theodore P, Neuhaus Emily, Gatzke-Kopp Lisa M, Reid M Jamila, Chipman Jane, Brekke Austin, Olliges Amanda, Shoemaker Shelby, Webster-Stratton Carolyn
Department of Psychology, The Ohio State University.
Seattle Children's Research Institute.
J Consult Clin Psychol. 2015 Apr;83(2):293-303. doi: 10.1037/a0038405. Epub 2014 Dec 8.
To evaluate electrodermal activity (EDA) as a prospective biomarker of treatment response, to determine whether patterns of EDA are altered by treatment, and to assess oppositional defiant disorder (ODD) as a possible moderator of trajectories in EDA after an empirically supported behavioral intervention for attention-deficit hyperactivity disorder (ADHD) in preschool.
Nonspecific fluctuations (NSFs) in skin conductance, which index sympathetic nervous system activity, were assessed among 4-6 year old children with ADHD (n = 99) before they participated with their parents in 1 of 2 versions of the Incredible Years intervention. All were reassessed at posttreatment, and a subgroup (n = 49) were assessed again at 1-year follow-up.
No difference in pretreatment NSFs was observed between ADHD participants and a group of normal control children (n = 41). Nevertheless, among those with ADHD, fewer NSFs at pretest predicted poorer treatment response on 4 of 7 externalizing outcomes. Furthermore, treatment was associated with increasing NSFs across time, but not for those who scored high on ODD at pretest.
Low EDA appears to mark resistance to treatment among preschoolers with ADHD. Furthermore, although our study was not experimental, treatment was associated with longitudinal increases in EDA, which were not observed in a normal control group. This may suggest increased sensitivity to discipline, with positive implications for long term outcome. In contrast to treated participants as a whole, however, those who scored high on ODD at pretest exhibited reduced EDA over time. (PsycINFO Database Record
评估皮肤电活动（EDA）作为治疗反应的前瞻性生物标志物，确定治疗是否会改变EDA模式，并评估对立违抗障碍（ODD）作为学龄前儿童注意缺陷多动障碍（ADHD）经实证支持的行为干预后EDA轨迹的可能调节因素。
在99名4至6岁ADHD儿童与其父母参与2个版本的“不可思议的岁月”干预中的1个之前，评估了作为交感神经系统活动指标的皮肤电导非特异性波动（NSFs）。所有儿童在治疗后均进行了重新评估，并且一个亚组（n = 49）在1年随访时再次进行了评估。
ADHD参与者与一组正常对照儿童（n = 41）之间在治疗前的NSFs上未观察到差异。然而，在患有ADHD的儿童中，预测试时较少的NSFs预示着7个外化结果中的4个治疗反应较差。此外，治疗与随时间增加的NSFs相关，但预测试时ODD得分高的儿童除外。
低EDA似乎标志着学龄前ADHD儿童对治疗的抵抗。此外，尽管我们的研究不是实验性的，但治疗与EDA的纵向增加相关，而在正常对照组中未观察到这种情况。这可能表明对纪律的敏感性增加，对长期结果具有积极意义。然而，与整个接受治疗的参与者相比，预测试时ODD得分高的儿童随着时间的推移EDA降低。（PsycINFO数据库记录）
