Iranzo Jaime, Lobkovsky Alexander E, Wolf Yuri I, Koonin Eugene V
a National Center for Biotechnology Information; National Library of Medicine; National Institutes of Health ; Bethesda , MD USA.
Cell Cycle. 2014;13(19):3083-8. doi: 10.4161/15384101.2014.949496.
Unicellular eukaryotes and most prokaryotes possess distinct mechanisms of programmed cell death (PCD). How an "altruistic" trait, such as PCD, could evolve in unicellular organisms? To address this question, we developed a mathematical model of the virus-host co-evolution that involves interaction between immunity, PCD and cellular aggregation. Analysis of the parameter space of this model shows that under high virus load and imperfect immunity, joint evolution of cell aggregation and PCD is the optimal evolutionary strategy. Given the abundance of viruses in diverse habitats and the wide spread of PCD in most organisms, these findings imply that multiple instances of the emergence of multicellularity and its essential attribute, PCD, could have been driven, at least in part, by the virus-host arms race.
单细胞真核生物和大多数原核生物拥有独特的程序性细胞死亡（PCD）机制。像PCD这样一种“利他”特性是如何在单细胞生物中进化的呢？为了解决这个问题，我们构建了一个病毒 - 宿主共同进化的数学模型，该模型涉及免疫、PCD和细胞聚集之间的相互作用。对该模型参数空间的分析表明，在高病毒载量和不完全免疫的情况下，细胞聚集和PCD的联合进化是最优的进化策略。鉴于不同生境中病毒的丰富性以及PCD在大多数生物中的广泛存在，这些发现意味着多细胞性及其基本属性PCD的多次出现，可能至少部分是由病毒 - 宿主军备竞赛驱动的。
