Shulyzki Ruslana, Abdelhalim Karim, Bagheri Arezu, Salam M Tariqus, Florez Carlos M, Velazquez Jose Luis Perez, Carlen Peter L, Genov Roman
IEEE Trans Biomed Circuits Syst. 2015 Feb;9(1):34-49. doi: 10.1109/TBCAS.2014.2312552. Epub 2014 Jun 4.
We present a 320-channel active probe for high-spatial-resolution neuromonitoring and responsive neurostimulation. The probe comprises an integrated circuit (IC) cell array bonded to the back side of a pitch-matched microelectrode array. The IC enables up to 256-site neural recording and 64-site neural stimulation at the spatial resolution of 400 μ m and 200 μ m, respectively. It is suitable for direct integration with electrode arrays with the shank pitch of integer multiples of 200 μm. In the presented configuration, the IC is bonded with a 8 × 8 400 μ m-pitch Utah electrode array (UEA) and up to additional 192 recording channels are used for peripheral neuromonitoring. The 0.35 μ m CMOS circuit array has a total die size of 3.5 mm × 3.65 mm. Each stimulator channel employs a current memory for simultaneous multi-site neurostimulation, outputs 20 μA-250 μA square or arbitrary waveform current, occupies 0.02 mm (2), and dissipates 2.76 μ W quiescent power. Each fully differential recording channel has two stages of amplification and filtering and an 8-bit single-slope ADC, occupies 0.035 mm (2) , and consumes 51.9 μ W. The neural probe has been experimentally validated in epileptic seizure propagation studies in a mouse hippocampal slice in vitro and in responsive neurostimulation for seizure suppression in an acute epilepsy rat model in vivo .
我们展示了一种用于高空间分辨率神经监测和响应性神经刺激的320通道有源探头。该探头包括一个与间距匹配的微电极阵列背面键合的集成电路（IC）单元阵列。该IC能够分别以400μm和200μm的空间分辨率进行多达256位点的神经记录和64位点的神经刺激。它适用于与柄间距为200μm整数倍的电极阵列直接集成。在所示配置中，IC与一个8×8、400μm间距的犹他电极阵列（UEA）键合，另外多达192个记录通道用于外周神经监测。0.35μm的CMOS电路阵列的总芯片尺寸为3.5mm×3.65mm。每个刺激器通道采用电流存储器进行同步多位点神经刺激，输出20μA - 250μA的方波或任意波形电流，占用0.02mm²，静态功耗为2.76μW。每个全差分记录通道有两级放大和滤波以及一个8位单斜率ADC，占用0.035mm²，功耗为51.9μW。该神经探头已在体外小鼠海马切片的癫痫发作传播研究以及体内急性癫痫大鼠模型的癫痫发作抑制响应性神经刺激实验中得到验证。
