Department of Urology, Northwestern University, Feinberg School of Medicine, Galter Pavilion, Suite 20-150, 675 North Saint Clair Street, Chicago, IL 60611, USA.
Best Pract Res Clin Obstet Gynaecol. 2015 May;29(4):507-15. doi: 10.1016/j.bpobgyn.2014.10.006. Epub 2014 Oct 24.
Metabolic syndrome is a compilation of symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension. Initially used to predict cardiovascular disease, it is now clear that the molecular and physiologic abnormalities seen in metabolic syndrome extend well beyond the cardiovascular system. Growing evidence has linked metabolic syndrome and its individual symptoms to the increasing prevalence of male infertility. This manuscript reviews the recent evidence connecting metabolic syndrome to male infertility as well as the underlying pathophysiology. Currently, there are limited prospective studies examining the effects of treating metabolic syndrome on male reproduction and these relationships will need to be a focus of further investigation.
代谢综合征是一组症状的集合，包括中心性肥胖、胰岛素抵抗、血脂异常和高血压。最初用于预测心血管疾病，现在很明显，代谢综合征中出现的分子和生理异常远远超出了心血管系统。越来越多的证据将代谢综合征及其各个症状与男性不育症的发病率上升联系起来。本文综述了最近将代谢综合征与男性不育联系起来的证据以及潜在的病理生理学。目前，关于治疗代谢综合征对男性生殖影响的前瞻性研究有限，这些关系需要进一步研究。
